不同疗程阿奇霉素治疗小儿支原体肺炎疗效及安全性比较

杨文岗

（陕西省延安市志丹县人民医院儿科一病区，陕西 延安，717500）

浏览次数：116次 下载次数：402次

摘要：

目的 探讨不同疗程的阿奇霉素治疗小儿支原体肺炎疗效及安全性。方法 选取2011年1月至2016年1月于我院进行治疗的小儿支原体肺炎患儿98例为研究对象，按照疗程不同将其分为观察组50例及对照组48例。观察组患儿单次阿奇霉素治疗>5d，对照组患儿单次阿奇霉素治疗≦ 5d，对两组患儿治疗效果及安全性进行分析与比较。结果 观察组患儿痊愈率及总有效率分别为32.00%及88.00%，对照组患儿痊愈率及总有效率分别为25.00%及87.50%，观察组患儿临床疗效高于对照组，但差异无统计学意义（P>0.05）。观察组患儿体温恢复正常时间及咳嗽消失时间与对照组相较无显著差异（P>0.05），但啰音消失时间及住院时间明显短于对照组，差异有统计学意义（P<0.05）。观察组不良反应发生率为2.00%，对照组不良反应发生率为6.25%，两组比较无显著差异（P>0.05）。结论 与单次阿奇霉素治疗≦ 5d相比，单次阿奇霉素治疗>5d可有效降低小儿支原体患儿啰音消失时间及住院时间，提高临床疗效。

关键词：小儿支原体肺炎；阿奇霉素；安全性

中图分类号：R725.6文献标志码：A文章编号：2096-1413(2017)11-0099-02

Clinical effect and safety of different course of azithromycin in treatment of children with mycoplasma pneumonia
YANG Wen-gang
(Department of Pediatrics Ward, Zhidan County People's Hospital of Yan'an, Yan'an 717500, China)

ABSTRACT: Objective To investigate the clinical effect and safety of different course of azithromycin in treatment of children with mycoplasma pneumoniae. Methods Ninety-eight children with mycoplasma pneumonia in our hospital from January 2011 to January 2016 were selected as research objects. All the children were divided into observation group with 50 cases and control group with 48 cases according to different treatment courses. Children in observation group were given azithromycin for >5 d, while children in control group were given azithromycin for ≦5 d. The clinical effect and safety of the two groups were observed and compared. Results The clinical cure rate and total efficiency of the observation group were 32.00% and 88.00% respectively, of control group were 25.00% and 87.50% respectively. The clinical effect of the observation group was higher than the control group but without statistically significance (P >0.05). The recovery time of tempreature and cough extinction time of the two groups had no statistically difference (P>0.05). But the rale extinction time and hispital stays of the observation group were obviously shorter than those of the control group, which difference was statistically significance (P <0.05). The adverse reaction rate of the observation group was 2.00%, of control group was 6.25%. There were no statistically difference of the two groups (P>0.05). Conclusion Compared with azithromycin for ≦5 d,
using azithromycin for >5 d has significantly better effect in rale extinction time and hispital stays, and it can improve the clinical curative effect.
KEYWORDS: mycoplasma pneumonia in children; azithromycin; safety

参考文献：
[1] 郭兆岩.小儿肺炎支原体肺炎的临床特点和诊治分析[J].饮食保健,2015,2(12):20-21.
[2] 吴倩,吴起武.儿童肺炎支原体感染流行病学的研究进展[J].中国妇幼保健,2016,31(5):1111-1114.
[3] 王红连,徐进.儿童难治性肺炎支原体肺炎危险因素及支原体耐药的相关性分析[J].临床肺科杂志,2016,21(4):678-682.
[4] 欧阳慧萍,陶志允,余飞苑.不同方式阿奇霉素治疗小儿支原体肺炎的临床效果比较[J].社区医学杂志,2014,12(5):47,79.
[5] 张莉娅.阿奇霉素治疗小儿支原体肺炎的疗效观察[J].中国医院用药评价与分析,2016,16(4):83.
[6] 谢圣全,谭毅.阿奇霉素在小儿支原体肺炎治疗中应用方法的研究进展[J].中国临床新医学,2015,35(10):1007-1010.
[7] 郭敏,李奎臣,刘建云,等.肺炎支原体肺炎患儿不同疗程阿奇霉素的应用效果研究[J].中华医院感染学杂志,2016,26(8):1882-1883,1889.

[8] 余德钊,徐嘉辉,韦泓娟,等.中药外治法联合大桑菊合剂口服治疗儿童肺炎支原体肺炎临床研究[J].中国中医药信息杂志,2016,23(3):23-26.