联合运用阿托伐他汀与曲美他嗪治疗不稳定型心绞痛30例疗效分析

马有利

（西安煤矿机械厂职工医院，陕西 西安，710032）

浏览次数：146次 下载次数：418次

摘要：

目的 观察阿托伐他汀联合曲美他嗪在不稳定型心绞痛临床治疗中的效果。方法 采用简单随机方法将60例不稳定型 心绞痛患者随机分为对照组和观察组，每组30例。两组患者均给予常规对症支持治疗，对照组在常规治疗的基础上给予阿托伐他汀治疗，观察组在常规治疗的基础上给予阿托伐他汀联合曲美他嗪治疗，比较两组患者的治疗总有效率，治疗前、后血脂指标改善情况及不良反应发生情况。结果 治疗8周后，观察组患者的总有效率达93.3%，高于对照组的73.3%（P<0.05）；观 察组患者TC、TG、LDL-C水平显著低于对照组，HDL-C含量显著高于对照组（P<0.05）；观察组患者的LVESD、LVEDD水平与对照组相比显著降低，LVEF水平与对照组相比显著升高（P<0.05）；两组患者的不良反应发生率差异不显著（P>0.05）。结论 采用阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛，临床效果显著，安全性好，值得推广应用。

关键词：阿托伐他汀；曲美他嗪；不稳定型心绞痛

中图分类号：R541.4文献标志码：A文章编号：2096-1413(2017)11-0008-02

Treatment efficacy analysis of atorvastatin combined with trimetazidine on 30 cases of patients with unstable angina
MA You-li
（Worker's Hospital of Xi'an Coal Mine Machinery Factory, Xi'an 710032, China）

ABSTRACT: Objective To observe the effect of atorvastatin combined with trimetazidine in the treatment of unstable angina. Methods Sixty cases of patients with unstable angina were randomly divided into control group and observation group, with 30 cases in each group. The two groups were given conventional support treatment, the control group was given atorvastatin on the basis of conventional treatment, while the observation group was given atorvastatin with trimetazidine on the basis of conventional treatment. The total effective rate, blood lipid indexes before and after treatment and adverse reactions occurrence rate were compared between the two groups. Results After 8 weeks treatment, the total effective rate of the observation group was 93.3%, which was significantly higher than 73.3% of the control group (P<0.05); the levels of TC, TG and LDL-C of the observation group were significantly lower than those of the control group, the level of HDL-C was significantly higher than that of the control group (P<0.05); the levels of LVESD and LVEDD in the observation groupwere significantly lower than those of the control group, the LVEF level were significantly higher than that of the control group (P<0.05); the difference of adverse reactions incidence rates had no statistical significance between the two groups (P >0.05). Conclusion The clinical effect of atorvastatin combined with trimetazidine in the treatment of patients with unstable angina is remarkable, it was of high security, which is worthy of clinical popularization and application.

KEYWORDS: atorvastatin; trimetazidine; unstable angina

参考文献：
[1] 谢学渊,王丽华,曾倩,等.曲美他嗪联合阿托伐他丁治疗不稳定型心绞痛的临床疗效分析[J].解放军药学学报,2014,30(4):174-176.
[2] 李大斌.脂曲美他嗪联合阿托伐他丁治疗不稳定心绞痛疗效分析[J].吉林医学,2014,35(13):2855-2856.
[3] 李艳卿,陈历雄,冯燕玲.曲美他嗪联合阿托伐他丁治疗不稳定行心绞痛临床观察[J].中国当代医药,2009,16(19):39-40.
[4] 赵涛,吴易珊.血清脂联素水平与糖尿病视网膜病变的相关性研究[J].中国医药指南,2013,5(19):104-105.
[5] 曹在新.曲美他嗪联合阿托伐他汀治疗不稳定性心绞痛疗效观察[J].临床心身疾病杂志,2008,14(4):362-363.
[6] 梁敏,王琴.阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛疗效观察[J].辽宁医学院学报,2014,35(6):22-24.
[7] 肖侃,李世煌,刘向儒,等.曲美他嗪联合阿托伐他汀治疗不稳定型心绞痛的疗效分析[J].中国医药指南,2013,11(30):104-105.
[8] 李素真.阿托伐他汀联合曲美他嗪治疗冠心病心绞痛的临床疗效分析[J].当代医学,2015,21(14):129-130.