老年中重度COPD患者应用舒利迭吸入治疗对肺功能的影响

沈海虎，佘飞龙

（陕西省定边县人民医院呼吸科，陕西 定边，718699）

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摘要：

目的 探究舒利迭吸入治疗对老年中重度慢性阻塞性肺疾病（COPD）患者肺功能的影响。方法 选择我院2012年1月至 2015年12月收治的160例老年中重度COPD患者，随机分为试验组和对照组，各80例。在常规治疗的基础上，对照组给予吸入辅舒酮加沙丁胺醇治疗，试验组给予舒利迭（沙美特罗替卡松气雾剂）吸入治疗，在入院当天及治疗后分别测定患者的 FVC、FEV1、FEV1/FVC及PaO2、PaCO2。结果 治疗后，试验组FVC为（3.85±0.49）L、FEV1 为（2.23±0.55）L、FEV1/FVC 为（57.92±3.85）%，对照组FVC 为（3.07±0.53）L、FEV1 为（1.97±0.42）L、FEV1/FVC为（51.94±4.13）%，两组患者肺功能均有不同程度的改 善，且试验组改善比对照组明显（P<0.05）；试验组PaO2为（73.86±4.59）mmHg，PaCO2 为（42.19±3.17）mmHg，对照组PaO2为（65.72依3.95）mmHg，PaCO2为（49.31±3.28）mmHg，两组患者PaO2均有不同程度提高，PaCO2均有不同程度降低，且试验组改善程度优于对照组（P<0.05）。结论 舒利迭改善中重度老年COPD患者的肺功能效果较好，值得临床推广。

关键词：慢性阻塞性肺疾病；舒利迭吸入；肺功能

中图分类号：R563.9文献标志码：A文章编号：2096-1413(2017)11-0010-02

The effect of seretide inhalation therapy on lung function in the elderly patients with moderate and severe COPD
SHEN Hai-hu, SHE Fei-long
(Department of Respiration, Dingbian County Hospital in Shaanxi Province, Dingbian 718699, China)

ABSTRACT: Objective To investigate the effect of seretide inhalation therapy on lung function in the elderly patients with moderate and severe COPD. Methods One hundred and sixty cases of elderly patients with moderate and severe COPD in our hospital from January 2012 to December 2015 were selected and randomly divided into experimental group and control group, with 80 cases in each group. On the basis of conventional therapy, the control group was treated with flixotide and salbntamol, while the experimental group was given seretide inhalation therapy. The FVC, FEV1, FEV1/FVC and PaO2, PaCO2 were measured on the day of admission and after treatment between the two groups. Results After treatment, the FVC, FEV1, FEV1/FVC of the experimental group respectively were (3.85依0.49) L, (2.23±0.55) L, (57.92±3.85)%, while the control group respectively were (3.07±0.53) L, (1.97±0.42) L, (51.94±4.13)%. The lung function indexes of the patients in the two groups were both improved, and the experimental group improved more significantly than the control group (P < 0.05). The PaO2, PaCO2 of the experimental group respectively were (73.86±4.59) mmHg, (42.19±3.17) mmHg, while the control group respectively were (65.72±3.95) mmHg, (49.31±3.28) mmHg. The PaO2 of the patients in the two groups were both improved, while the PaCO2 of the patients in two groups were both reduced, and the experimental group was better than the control group (P <0.05). Conclusion The effect of seretide inhalation therapy on lung function in the elderly patients with moderate and severe COPD is better, which is worthy of clinical promotion.
KEYWORDS: chronic obstructive pulmonary disease (COPD); seretide inhalation; lung function

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