中国学术期刊网络出版总库入编期刊
CNKI中文期刊全文数据库全文收录期刊
中国核心期刊(遴选)数据库全文收录期刊
万方数据——数字化期刊群收录期刊
中文科技期刊数据库全文收录期刊

主管:陕西省卫生健康委员会
主办:西安心身医学研究所
   西安交通大学第一附属医院
国际标准刊号:ISSN2096—1413
国内统一刊号:CN61—1503/R

血浆脑钠肽前体测定对心源性脑栓塞的诊断价值

金亚娟,赵秋芬

(杨凌示范区医院,陕西 咸阳,712100)

浏览次数:149次 下载次数:297次

摘要:

目的 探讨血浆脑钠肽前体(pro-BNP)检测对心源性脑栓塞的诊断价值。方法 随机选取2014年9月至2015年5月我院收治的急性脑梗死患者228例,检测患者血浆pro-BNP水平,根据TOAST诊断分为A组(心源性脑栓塞组),B组(大动脉 粥样硬化组),C组(小动脉闭塞组)和D组(其他),比较各组间pro-BNP水平。结果 A 组pro-BNP水平明显高于其他组(P<0.05),
其他三组间的血浆pro-BNP水平比较,差异不明显(P>0.05)。结论 血浆pro-BNP水平的检测对心源性脑栓塞的诊断有价值,有利于临床脑梗死的病因分型,有利于心源性脑栓塞的诊断。

关键词:心源性脑栓塞;pro-BNP;诊断价值

中图分类号:R743.3文献标志码:A文章编号:2096-1413(2017)16-0046-02

    Diagnostic value of brain natriuretic peptide precursor determine on cardiogenic cerebral embolism
    JIN Ya-juan, ZHAO Qiu-fen
    (Yangling Demonstration Zone Hospital, Xianyang 712100, China)

    ABSTRACT: Objective To study the diagnostic value of brain natriuretic peptide precursor determine on cardiogenic cerebral embolism. Methods From September 2014 to May 2015, 228 cases patients with acute cerebral infarction admitted in our hospital were selected. All the patients were detected brain natriuretic peptide precursor (pro-BNP). According to TOAST diagnosis, all the patients were divided into group A (cardiac cerebral embolism group), group B (artery atherosclerosis group), group C (small artery occlusion group) and group D (others). The levels of pro-BNP between the four groups were compared. Results The pro-BNP level of group A was significantly higher than that of other groups (P<0.05); there were no significant differences on pro-BNP level between other three groups (P>0.05). Conclusion The pro-plasma BNP level detection has a value on the diagnostic of cardiogenic cerebral embolism, and it is beneficial to cause classification of cerebral infarction, which is helpful to the diagnosis of cardiac cerebral embolism.
    KEYWORDS: cardiac cerebral embolism; pro-BNP; diagnostic value

    参考文献:
    [1] 徐安定,刘小亚,赵颖.心源性与主动脉弓源性脑栓塞的诊断策略 [J].中国神经精神疾病杂志,2011,37(1):3-6.
    [2] 肖美娟,殷为勇,叶祖森,等.心源性脑栓塞和大动脉粥样硬化性脑梗死患者自发性出血性转化的发生及相关因素分析[J].中华全科医 师杂志,2014,13(10):848-850.
    [3] 王志宏,韩仲岩.急性缺血性脑卒中的TOAST分型标准[J].临床神经病学杂志,2007,20(5):392.
    [4] 王新德.各类脑血管疾病诊断要点(1986 年中华医学会第二次全国脑血管病学术会议第三次修订)[J].中华精神科杂志,1988,21(1):60.

    [5] 于农,金欣,孙君,等.血清NT-pro-BNP水平与NYHA心功能分级的相关性研究[J].现代检验医学杂志,2008,23(4):113-114.
    [6] 李靖,刘延玲,何青,等.正常人群年龄进程中心脏结构和功能的变化特点[J].中华心血管杂志,2010,38(1):52-56.
    [7] 洪敏,刘剑凯,鲍涛,等.肾上腺皮质激素对心房钠尿肽基因表达的促进作用[J].生理学报,1991,43(5):494-498.
    [8] 马建新,陈东,宋成运,等.不同起搏模式对老年患者B型钠尿肽及相关神经内分泌激素水平的影响[J].中华老年心脑血管病杂志,2013,15(6):563-565.
    [9] EMANUELE DA,STELANO DC,DANILO T,et al.Deteminants of pasma levels of brain natriuretic peptide after acute ischemic stroke or TIA[J].J Neurol Sci,2007,260(1-2):139-142.
    [10] MCGIRT MJ,BLESSING R,NIMJEE SM,et al.Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage[J].Neurosurg,2004,54 (6):1369-1374.
    [11] PIERALLI F,OLIVOTTO I,VANNI S,et al.Usefulness of bedside testing for brain natriuretic peptide to identify right ventricular dysfunction and outcome in normotensive patients with acute pulmonary embolism[J].Am J Cardiol,2006,97(9):1386-1390.
    [12] PROSEN G,KLEMEN P,STRNAD M,et al.Combination of lung ultrasound (a comet -tail sign) and N -terminal pro -brain natriuretic peptide in differentiating acute heart failure from chronic obstructive pulmonary disease and asthma as cause of acute dyspnea in prehospital emergency setting[J].Criti Care,2011,15(2):R114.
    [13] MAYR A,MAIR J,SCHOCKE M,et al.Predictive value of NT -pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function[J].Int J Cardiol,2011,147(1):118-123.
    [14] LI X,CHEN C,GAN F,et al.Plasma NT pro-BNP, hs-CRP and big-ET levels at admission as prognostic markers of survival in hospitalized patients with dilated cardiomyopathy: a single -center cohort study [J]. BMC Cardiovasc Disord,2014,14(1):67.
    [15] KLECZYNSKI P,LEGUTKO J,RAKOWSKI T,et al.Predictive utility of NT -pro BNP for infarct size and left ventricle function after acute myocardial infarction in long-term follow-up[J].Dis Markers,2013,34(3): 199-204.

上一篇抗生素与糖皮质激素联合治疗老年慢性阻塞性肺气肿的临床效果

下一篇胺碘酮治疗心力衰竭合并快速型室上性心动过速的临床效果