二甲双胍联合苯甲酸阿格列汀治疗Ⅱ型糖尿病的临床观察

刘开宇

（枣庄矿业集团东郊医院，山东 枣庄，277119）

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摘要：

目的 观察二甲双胍联合苯甲酸阿格列汀治疗域型糖尿病的临床疗效。方法 选择我院Ⅱ域型糖尿病患者80例，随机分为对照组和观察组，各40例。对照组采用二甲双胍联合维格列汀治疗，观察组采用二甲双胍联合苯甲酸阿格列汀治疗。比较两组患者治疗前后的生化指标，包括空腹血糖（FBG）、身体质量指数（BMI）、餐后2h血糖（2hPBG）、糖化血清蛋白（GSP）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）。结果 治疗后，观察组患者的FBG、BMI、2 h PBG、GSP、HbA1c、TC、TG、LDL-C、HDL-C 标均较治疗前显著下降（P<0.05），HDL原C指标显著上升（P<0.05）；而对照组仅FBG、BMI、2hPBG、GSP、HbA1c、TG较治疗前明显下降（P<0.05）。结论 二甲双胍联合苯甲 酸阿格列汀治疗域型糖尿病的效果较二甲双胍联合维格列汀治疗效果好，可以在临床中推广使用。

关键词：二甲双胍；苯甲酸阿格列汀；维格列汀

中图分类号：R587.1文献标志码：A文章编号：2096-1413(2017)04-00圆怨-02

Clinical observation of metformin combined with alogliptin benzoate in treatment of type II diabetes
LIU Kai-yu
(Eastern Hospital of Zaozhuang Mining Group, Zaozhuang 277119, China)

ABSTRACT: Objective To observe the clinical effect of metformin combined with alogliptin benzoate in treatment of type II diabetes. Methods Eighty patients with typeⅡ diabetes mellitus were selected and randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with metformin and vildagliptin for treatment, while the observation group was treated with metformin combined with alogliptin benzoate for treatment. The biochemical parameters including fasting blood glucose (FBG), body mass index (BMI), 2 h postprandial blood glucose (2 h PBG), glycosylated serum protein (GSP), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were compared between the two groups before and after treatment. Results After treatment, the FBG, BMI, 2 h PBG, GSP, HbA1c, TC, TG, LDL-C and HDL-C of the observation group were significantly lower than those before treatment (P<0.05), HDL-C was significantly increased (P<0.05). While the FBG, BMI, 2 h PBG, GSP, HbA1c, TG of the control group were significantly lower than those before treatment (P<0.05). Conclusion Metformin combined with alogliptin benzoate has a better treatment effect in the treatment of type 2 diabetes than metformin combined with vildagliptin, which can be used in clinical practice.

KEYWORDS: metformin; alogliptin benzoate; vildagliptin

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