血浆同型半胱氨酸与缺血性脑血管病患者颈动脉 粥样硬化斑块的关系

梁小宁

西安市高陵区中医医院，陕西 西安，710200

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摘要：

目的 研究血浆同型半胱氨酸（Hcy）与缺血性脑血管病（ICVD）患者颈动脉粥样硬化斑块的相关性。方法 选择本院收治的150例 ICVD 患者，所有患者均行颈动脉彩超检查，根据检查结果分为无斑块组、不稳定斑块组和稳定斑块组，对各组患者血浆Hcy水平进行检测。结果 不稳定斑块组和稳定斑块组 Hcy水平均高于无斑块组，且不稳定斑块组 Hcy水平高于稳定斑块组（P<0.05）；Hcy浓度高、血脂异常、吸烟史、高血压为 ICVD 患者颈动脉粥样硬化（AS）不稳定斑块形成的独立危险因素（P<0.05）。结论 ICVD 患者颈 AS斑块的形成和稳定性与血浆 Hcy有密切联系，临床可将 Hcy水平上升作为颈动脉斑块形成的高危因素。

关键词： 血浆同型半胱氨酸；缺血性脑血管病；颈动脉粥样硬化斑块

中图分类号：R743.3文献标志码：A文章编号： 2096-1413(2018)09-0038-02

Relationship between plasma homocysteine and carotid atherosclerotic plaque in
patients with ischemic cerebrovascular disease


LIANG Xiao-ning
(TraditionalChineseMedicineHospitalofGaolingDistrict,Xi````an 710200,China)



ABSTRACT: Objective To study the correlation between plasma homocysteine(Hcy)and carotid atheroscleroticplaquein patients with ischemic cerebrovascular disease (ICVD). Methods A total of 150 patients with ICVD were enrolled in this study. All patients under went carotid artery ultrasonography. According to the results of ultrasonography, patients were divided into no plaque group,unstable plaque group and stable plaque group. Plasma Hcy levels were detected in each
group. Results The levels of Hcy in the unstable plaque and the stable plaque group were higherthan those in the no plaque group,and the level of Hcyin the unstableplaque group was higher than that in the stable plaque group (P<0.05).
High Hcy concentration,dyslipidemia,smoking history,hypertension were the risk factors of unstable plaque formed inICVD patients with carotid atherosclerosis (AS)plaques (P<0.05). Conclusion The formation and stability ofcarotid AS
plaquesin patientswith ICVD arecloselyrelated toplasmaHcy.IncreasingofHcylevelscan be regarded asthehigh risk
factor sofcarotid plaqueformed in theclinic.
KEYWORDS: plasmahomocysteine; ischemic cerebrovascular disease;carotid atherosclerotic plaque

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