不同促排卵方式对人工授精后妊娠结局的影响

李丽 1 ，王雁林 1,2

1.滨州医学院，山东 烟台，264003；2.滨州医学院附属医院，山东 烟台，256603

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摘要：

目的 探讨不同促排卵方式对人工授精后妊娠结局的影响。方法 对 167例接受人工授精的患者及配偶的临床资料进行回顾性分析，根据促排卵方式不同，将研究对象分为来曲唑组（n=79）和克罗米芬组（n=88）。比较两组患者的性激素水平、窦卵泡数及妊娠结局。结果 两组患者 E、FSH、LH、T 水平、窦卵泡数、活产率、自然流产率及临床总妊娠率比较，差异无统计学意义（P>0.05）。两组患者第 1耀4周期妊娠率、多胎妊娠率及异位妊娠率比较，差异有统计学意义（P<0.05）。结论 在促排卵药物选择中，来曲唑比克罗米芬更适合应用于人工授精治疗。

关键词： 促排卵；人工授精；来曲唑；克罗米芬

中图分类号：R714.8文献标志码：A文章编号：2096-1413(2018)09-0003-03

Influence of different ovarian hyper-stimulation methods on pregnancy outcome
after intrauterine insemination

LILi 1 ,WANG Yan-lin 1,2*
(1.Binzhou Medical University,Yantai264003;2.Binzhou Medical University Hospital,Yantai256603,China)




ABSTRACT: Objective To investigate the effects of different ovarian hyper-stimulation methods on pregnancy outcome after intrauterine insemination. Methods The clinical data of 167 patients with intrauterine insemination and their spouses were retrospectively analyzed. All the patients were divided into letrozole group (n=79)and clmiphene citrateclinical group (n=88) according to the different ovarian hyper-stimulation drugs. The sex hormone levels, number of antral follicles and pregnancy outcomes were compared between the two groups. Results There were no significant differences in levels of E,FSH,LH and T,number of antral follicles, live birth rate,natural abortion rate and clinical total pregnancy rate between the two groups (P>0.05).There were significant differences in pregnancy rate at1-4 circle,multiple pregnancy rate and ectopicpregnancy rate(P<0.05). Conclusion Compared with clmiphene citrate, letrozole as the drug of ovarian hyper-stimulation on the process of intrauterine insemination has superiority.
KEYWORDS: ovarian hyper-stimulation; intrauterine insemination; letrozole; clmiphene citrate

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