支气管哮喘对儿童身高、体重、骨密度的影响及吸入糖皮质激素 1 年后变化分析

冯敏娟 1 ，高育红 2*

1 . 高陵区医院，陕西 西安，710200 ；2 . 高陵区妇幼保健院，陕西 西安，710200

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摘要：

目的 探讨支气管哮喘对儿童身高、体重、骨密度的影响及吸入糖皮质激素 1 年后的变化。方法 将 2014 年 9 月至 2016 年 9 月在我院接受治疗的 53 例支气管哮喘患儿作为观察组，均接受糖皮质激素吸入治疗 1 年；选择同期健康体检的 50 例儿童作为对照组。比较两组身高、体重及骨密度。结果 入组时，观察组的身高、体重及骨密度均显著低于对照组（P<0.05）。重度哮喘患儿身高、体重及骨密度均明显低于轻、中度哮喘患儿（P<0.05）。两组 1 年内身高、体重及骨密度增量比较，无明显差异（P>0.05）。结论 支气管哮喘对儿童的身高、体重及骨密度存在影响，且病情越重，影响越大。吸入糖皮质激素 1 年不影响哮喘患儿的骨质发育。

关键词：支气管哮喘；儿童；吸入糖皮质激素；生长发育；骨密度

中图分类号：R725.6文献标志码：A文章编号：2096-1413(2018)08-0082-02

Effects of bronchial asthma on height, weight and bone mineral density in children and changes after 1 years of inhaled corticosteroids

FENG Min-juan 1, GAO Yu-hong 2 *

(1. Xi``an Gaoling Hospital, Xi``an 710200; 2. Gaoling District Maternal and Child Health Care Hospital, Xi``an 710200, China)

ABSTRACT: Objective To investigate the effect of bronchial asthma on height, weight and bone mineral density in children and the changes after 1 year of inhaled corticosteroids. Methods A total of 53 children with bronchial asthma treated with inhaled corticosteroids for 1 year in our hospital from September 2014 to September 2016 were enrolled as observation group. A total of 50 healthy children were selected as control group at the same period. The height, weight and bone mineral density were compared between the two groups. Results At enrolling the group, the height, weight and bone mineral density of the observation group were significantly lower than those of the control group (P<0.05). The height, weight and bone mineral density were significantly lower in children with severe asthma than those with mild or moderate asthma (P <0.05). There were no significant differences in the increments of height, weight and bone mineral density between the two groups in 1 year (P>0.05). Conclusion Bronchial asthma has influence on the height, weight and bone density of children, and the heavier the disease is, the greater the influence is. Inhaled corticosteroids for 1 years does not affect the bone development in children with asthma.
KEYWORDS: bronchial asthma; children; inhaled corticosteroids; growth and development; bone mineral density

 

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