盐酸小檗碱对于2型糖尿病合并肥胖患者的疗效 及糖尿病病情进展的作用

毋文江

扶风县中医医院内分泌科，陕西 宝鸡，722299

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摘要：

目的 分析盐酸小檗碱治疗 2 型糖尿病合并肥胖患者的临床疗效。方法 选取本院 2015年 1月至 2016年 6月收治的126例 T2DM 合并肥胖患者作为观察对象，将其随机分为对照组与观察组，各 63例。对照组给予二甲双胍治疗，观察组给予盐酸小檗碱联合二甲双胍治疗，治疗 3个月后比较两组患者的临床疗效。结果 治疗前，两组患者的血糖、血脂、肥胖指标及AI值比较，差异不显著（P>0.05）；治疗后，两组患者的 FPG、2 h PG、HbA1c、TC、TG 水平及 HOMA-IR、BMI、AI值显著降低，观察组以上指标水平均低于对照组（P<0.05）。结论 盐酸小檗碱治疗 2型糖尿病合并肥胖患者疗效理想，可明显改善患者症状。

关键词：盐酸小檗碱；2型糖尿病；肥胖

中图分类号：R587.1 文献标志码：A文章编号：2096-1413(2018)07-0046-02

Effect of berberine hydrochloride on the efficacy and progress of diabetes mellitus
of type2 diabetes mellitus patients with obesity


WU Wen-jiang
(Endocrinology Department,Traditional Chinese Medicine Hospital of Fufeng County, Baoji 722299, China)



ABSTRACT: Objective To analyze the clinical effect of berberine hydrochloride in type 2 diabetes mellitus (T2DM)  patients with obesity. Methods  One hundred and twenty-six cases of obese patients with T2DM in our hospital from January 2015 to June 2016 were selected, and randomly divided into control group and observation group, with 63 cases in each group.The control group was given metformin,while the observation group was given berberinehy drochloride combined with metformin.Three months after treatment, the clinical efficacy of the two groups was compared. Results  Before treatment,there were no significant differences between the two groups in blood glucose,blood lipid,obesity indexes and AIvalue (P>0.05). After treatment,the levels of FPG, 2hPG,HbA1c,BMI,TC,TG,HOMA-IR and AIvalue of the two groups significantly decreased, and those of the observation group were lower than the control group (P<0.05). Conclusion Berberine hydrochloride is effective in the treatment of T2DM patients with obesity, it can obviously improve patients clinical snydrome.                                                 KEYWORDS: berberinehy  drochloride;  type 2 diabetes  mellitus; obesity

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