急性脑梗塞采取氯吡格雷联合阿司匹林治疗 对患者血清PPARγ水平的影响

李蔚

（延安大学咸阳医院神经内科，陕西 咸阳，712000）

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摘要：

目的 探讨氯吡格雷联合阿司匹林治疗急性脑梗塞对患者血清PPARγ 水平的影响。方法 选择本院收治的急性脑梗塞患者84 例，以随机信封法分为对照组和联合组，各42 例。两组均采取维持水电解质平衡、降低颅内压的常规治疗，对照组在此基础上采取 阿司匹林治疗，联合组采取氯吡格雷联合阿司匹林治疗，对两组患者治疗效果进行观察对比。结果治疗后，两组的PPARγ 水平、梗死面积均降低，ESS 评分均升高，且联合组优于对照组（P<0.05）。两组患者的不良反应总发生率对比，无显著差异（P>0.05）。结论 氯吡格雷联合阿司匹林治疗急性脑梗塞可降低患者血清PPARγ 水平，控制梗死病灶进展，改善神经功能缺损症状，且用药安全。

关键词：急性脑梗塞；氯吡格雷；阿司匹林；血清PPARγ

中图分类号：R743.3 文献标志码：A文章编号：2096-1413(2018)06-0044-02

Effect of clopidogrel combined with aspirin on serum PPARγ levels in patients with acute cerebral infarction
LI Wei
(Neurology Department, Xianyang Hospital of Yan``an University, Xianyang 712000, China)

ABSTRACT: Objective To investigate the effect of clopidogrel combined with aspirin on serum levels of PPARγ in patients with acute cerebral infarction. Methods A total of 84 cases of patients with acute cerebral infarction admitted in our hospital were selected and divided into control group and combination group with the randomized envelope method, with 42 cases in each group. Both groups took the routine treatment such as maintaining the balance of water and electrolyte and reducing intracranial pressure. On this basis, the control group took aspirin treatment, and the combination group received clopidogrel combined with aspirin. The treatment effects of the two groups were observed and compared. Results After treatment, the levels of PPARγ and infarction size in both groups decreased, and the ESS scores increased, and those in the combination group were bettter than the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Clopidogrel combined with aspirin in the treatment of acute cerebral infarction can reduce serum PPARγlevels, control the progress of infarction, improve neurological deficit symptoms, which has medication safety.
KEYWORDS: acute cerebral infarction; clopidogrel; aspirin; serum PPARγ

参考文献：
[1] 王英海,张爱华,尹勇,等.氯吡格雷联合阿司匹林治疗急性脑梗死的效果及对血清PPARγ水平的影响分析[J].解放军预防医学杂 志,2016,34(s2):210-211.
[2] 邵鹏总.神经内科常见病诊疗精要[M].西安:西安交通大学出版社,2015.
[3] 华键,周其达,秦琳.急性脑梗死面积与血清胆红素水平的关系探讨[J].中国实用神经疾病杂志,2017,20(1):68-70.
[4] 金雪红,李霞,姚潇涵,等.多量表对急性脑梗死静脉溶栓的疗效评价[J].吉林医学,2016,37(2):332-335.
[5] 孔杰辰,李美玉,赵颖宇,等.探究急性脑梗死患者血清PPAR酌 检测的意义[J].中国临床实用医学,2016,7(1):62-63.
[6] 翟凤国,李厚忠,周福波,等.蒺藜皂苷对局灶性脑缺血大鼠脑组织PPARγ 和NF-资B 炎症信号途径表达的影响[J].医学综述,2015,21(24):4539-4540.
[7] 卢丽敏.氢氯吡格雷联合拜阿司匹林治疗急性脑梗死患者100 例临床分析[J].陕西医学杂志,2016,45(12):1671-1673.
[8] 黄剑,肖春蓉,詹茜.阿司匹林联合氯吡格雷治疗急性进展性脑梗塞的临床疗效观察[J].世界中医药,2015,10(a1):211-212.