特利加压素联合生长抑素治疗肝硬化上消化道出血的临床效果
王敏莉
（陕西省白水县医院内一科，陕西 渭南，715600）
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摘要：
目的 探讨特利加压素联合生长抑素治疗肝硬化上消化道出血的临床效果。方法 选取2016 年6 月至2017 年3 月我 院收治的肝硬化上消化道出血患者78 例为研究对象，随机分为试验组和对照组，每组39 例。在常规治疗基础上，对照组患 者给予生长抑素治疗，试验组患者给予特利加压素联合生长抑素治疗。比较两组患者的临床效果、止血情况和不良反应发生 率。结果 两组患者的治疗总有效率及不良反应总发生率比较，差异无统计学意义（P>0.05）；试验组患者的平均止血时间、48 h 再出血率、输血量及大便隐血转阴时间均优于对照组（P<0.05）。结论 特利加压素联合生长抑素治疗肝硬化上消化道出血的 临床效果优于单用生长抑素治疗，可显著改善患者的临床症状，且不增加不良反应。
关键词：特利加压素；生长抑素；肝硬化；上消化道出血
中图分类号：R575.2文献标志码：A文章编号：2096-1413(2018)06-0024-02
Clinical effect of terlipressin combined with somatostatin in the treatment of liver cirrhosis with upper
gastrointestinal bleeding
WANG Min-li
(No.1 Internal Medicine Department, the Hospital of Baishui County, Weinan 715600, China)
ABSTRACT: Objective To investigate the effect of terlipressin combined with somatostatin in the treatment of liver cirrhosis with upper gastrointestinal bleeding. Methods Seventy-eight patients with liver cirrhosis and upper gastrointestinal bleeding admitted in our hospital from June 2016 to March 2017 were selected as the research objects, and randomly divided into experimental group and control group, with 39 cases in each group. On the basis of routine treatment, the control group was treated with somatostatin, and the experimental group was given terlipressin combined with somatostatin. The clinical efficacy, hemostasis and adverse reactions were compared between the two groups. Results The total effective rate and total incidence of adverse reactions of the two groups were not statistically significant (P>0.05). The average hemostasis time, 48 h bleeding rate, blood transfusion volume and fecal occult blood clearance time in the experimental group were better than those in the control group (P<0.05). Conclusion Terlipressin combined with somatostatin in the treatment of liver cirrhosis with upper gastrointestinal bleeding has better clinical effect than the single use of somatostatin therapy, which can significantly improve the clinical symptoms of the patients, and do not increase the incidence of adverse reactions.
KEYWORDS: terlipressin; somatostatin; liver cirrhosis; upper gastrointestinal bleeding
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