短期布地奈德混悬液经鼻雾化治疗慢性鼻窦炎伴鼻息肉的疗效和安全性

邢亮，李菊芬

（铜川市人民医院耳鼻喉科，陕西 铜川，727000）

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摘要：

目的 探讨慢性鼻窦炎伴鼻息肉患者经鼻雾化给予短期布地奈德混悬液治疗的临床效果。方法 选取2015 年1 月至2016 年12 月于我院就诊的慢性鼻窦炎伴鼻息肉患者300 例，按照盲选法将患者分为对照组和观察组，各150 例。对照组给予甲 泼尼龙口服，观察组给予短期布地奈德混悬液经鼻雾化吸入。比较治疗后两组患者的VAS、内镜Kennedy 评分和晨起血清糖 皮质激素浓度。结果 治疗后，两组患者的Kennedy 及VAS 评分均明显低于治疗前，观察组均低于对照组（P<0.05）。治疗后，两组患者血清糖皮质浓度均降低（P<0.05），但观察组高于对照组（P<0.05）。结论 经鼻雾化吸入布地奈德混悬液治疗慢性鼻 窦炎伴鼻息肉的临床疗效显著，缩小了息肉体积，无其他不良影响，临床使用安全性高。

关键词：慢性鼻窦炎；鼻息肉；经鼻雾化吸入；布地奈德混悬液

中图分类号：R765.9文献标志码：A文章编号：2096-1413(2018)06-0022-02

Efficacy and safety of short-term budesonide suspension for nasal sinusitis in patients with chronic

sinusitis and nasal polyps
XING Liang, LI Ju-fen
(ENT Department, People``s Hospital of Tongchuan, Tongchuan 727000, China)

ABSTRACT: Objective To investigate the clinical effect of short-term budesonide suspension for nasal sinusitis in patients with chronic sinusitis and nasal polyps. Methods A total of 300 patients with chronic sinusitis and nasal polyps treated in our hospital from January 2015 to December 2016 were selected and divided into control group and observation group according to the method of blind selection, with 150 cases in each group. The control group was given methylprednisolone orally, while the observation group was given short-term budesonide nasal inhalation. The VAS scores were compared between the two groups after treatment, and the endoscopic Kennedy scores and morning serum glucocorticoid were also measured. Results After treatment, the Kennedy and VAS scores of the two groups were significantly lower than those before treatment, and those in the observation group were lower than the control group (P<0.05); the serum glucocorticoid concentrations decreased in both groups (P<0.05), but that of the observation group was higher than the control group (P<0.05). Conclusion The clinical effect of nasal atomizing inhalation of budesonide suspension in the treatment of chronic sinusitis with nasal polyps is significant. It can reduce the volume of polyps, and has fewer adverse effects, with high safety.
KEYWORDS: chronic sinusitis; nasal polyps; nasal nebulization; budesonide suspension

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