早期对新生儿溶血病患儿进行静脉注射丙种球蛋白的临床效果

刘春娟

（陕西省扶风县妇幼保健院，陕西 宝鸡，722200）

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摘要：

目的 探讨和分析早期对新生儿溶血病患儿进行静脉注射丙种球蛋白的临床治疗效果。方法 本研究选择2011 年3 月 至2016 年12 月在我院进行治疗的120 例新生儿溶血病患儿作为研究对象，按患儿入院顺序均分为观察组（67 例）和对照组（53 例）。两组患儿均通过常规疗法进行治疗，观察组患儿在早期静脉注射丙种球蛋白，评价两组患儿的血清总胆红素水平 及各临床指标。结果 治疗前，两组患儿血清总胆红素水平比较，差异不显著（P>0.05）；治疗后1、3 d，两组患儿的血清总胆红 素水平均低于治疗前，且观察组低于对照组，差异显著（P<0.05）。观察组患儿的光疗时间、黄疸消退时间及住院时间均短于 对照组，差异显著（P<0.05）。结论 在新生儿溶血病治疗中，早期静注丙种球蛋白的效果确切，有效缩短了患儿的黄疸消退、光 疗及住院时间，明显改善了血清总胆红素水平，值得推广。

关键词：新生儿溶血病；静脉注射；丙种球蛋白

中图分类号：R722.1文献标志码：A文章编号：2096-1413(2018)01-0096-02

Clinical effect of early intravenous injection of gamma globulin in children with hemolytic disease of newborns
LIU Chun-juan
(Maternal and Child Care Health of Fufeng County, Baoji 722200, China)

ABSTRACT: Objective To explore and analyze the clinical effect of early intravenous injection of gamma globulin in children with hemolytic disease of newborn. Methods From March 2011 to December 2016, 120 children with hemolytic disease of newborn in our hospital were selected as the study objects. Children were divided into observation group (67 cases)and control group (53 cases) according to the order of hospitalization. Both groups were treated by conventional therapy, then the children in the observation group were given early intravenous injection of gamma globulin. The level of serum total bilirubin and the clinical indexes in both groups were evaluated. Results Before treatment, the serum total bilirubin levels were not significantly different between the two groups (P>0.05). At the 1 and 3 d after treatment, the levels of serum total bilirubin in both groups were lower than those before treatment, and that in the observation group was lower than the control group, the differences were significant (P<0.05). The phototherapy time, jaundice``s remission time and hospitalization time in the observation group were shorter than those in the control group, the differences were significant (P<0.05). Conclusion In the treatment of hemolytic disease of newborn, early intravenous injection of gamma globulin has significant effect, it can effectively shorten the children``s time of jaundice``s remission, phototherapy, hospitalization, and significantly improve the serum total bilirubin levels, which is worthy of application.
KEYWORDS: hemolytic disease of newborns; intravenous injection; gamma globulin

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