补肾壮骨中成药治疗绝经后骨质疏松症机理的临床研究

周喜玲1，朱爱英2

（1.陕西煤炭建设公司总医院，陕西 铜川，727000；2.铜川市中医医院，陕西 铜川，727000）

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摘要：

目的 研究补肾壮骨中成药对绝经后骨质疏松症的治疗机理及其治疗效果。方法 将2014年1月1日至2016年1月31日在本院接受治疗的86 例绝经后骨质疏松症患者作为研究对象，并随机分成对照组（给予钙剂+活性维生素D）和观察组（给予钙剂+活性维生素D+补肾壮骨中成药），每组43 例。对比两组患者各阶段的尿钙/肌酐值、尿Ⅰ型胶原羧基末端肽/肌酐 值及腰椎和股骨颈部位的骨密度。结果 两组患者用药前、用药3、6 个月时的尿钙/肌酐值组间及组内比较，差异不显著（P> 0.05）。用药3个月时，两组患者的尿Ⅰ型胶原羧基末端肽/肌酐值均低于用药前（P<0.05）；用药6 个月时，两组患者的尿Ⅰ型 胶原羧基末端肽/肌酐值均低于用药前和用药3 个月时，且对照组明显低于观察组（P<0.05）。用药12 个月后，观察组股骨颈 的骨密度明显大于用药前，且大于与对照组（P<0.05）。结论 滋补肝肾、填补肾精为补肾壮骨中成药的治疗机理，应用在绝经 后骨质疏松症患者中效果显著。

关键词：补肾壮骨中成药；绝经后骨质疏松症；治疗机理

中图分类号：R259文献标志码：A文章编号：2096-1413(2017)35-0107-02

Clinical study on mechanism of Bushen Zhuanggu Chinese medicine on postmenopausal osteoporosis
ZHOU Xi-ling 1, ZHU Ai-ying 2
(1. General Hospital of Shaanxi Coal Construction Company, Tongchuan 727000; 2. Traditional Chinese

Medicine Hospital of Tongchuan, Tongchuan 727000, China)

ABSTRACT: Objective To study the therapeutic mechanism and therapeutic effect of Bushen Zhuanggu Chinese medicine on postmenopausal osteoporosis. Methods Eighty-six patients with postmenopausal osteoporosis treated in our hospital from January 1, 2014 to January 31, 2016 were enrolled in the study, and patients were randomly divided into control group (was given calcium+active vitamin D) and observation group (was given calcium+active vitamin D+Bushen Zhuanggu Chinese medicine), with 43 cases in each group. The urinary calcium/creatinine, urinary collagen type Ⅰ carboxy-terminal peptide/ creatinine and bone density of lumbar and femoral neck were compared between two groups. Results There were no significant differences in urinary calcium / creatinine between and in the two groups before treatment and at 3, 6 months after treatment (P>0.05). At 3 months after treatment, the urinary collagen type Ⅰ carboxy-terminal peptide/creatinine in both groups were lower than those before treatment (P<0.05). At 6 months after treatment, the urinary collagen type Ⅰ carboxy-
terminal peptide/creatinine in both groups were lower than those before treatment and at 3 months after treatment, and that of the control group was significantly lower than the observation group (P<0.05). At 12 months after treatment, the bone density of femoral neck in the observation group was significantly higher than that before treatment, and higher than that of the control group (P<0.05). Conclusion The treatment mechanism of Bushen Zhuanggu Chinese medicine is nourishing liver and kidney, filling kidney essence, the application of which is effective in patients with postmenopausal osteoporosis.

KEYWORDS: Bushen Zhuanggu Chinese medicine; postmenopausal osteoporosis; treatment mechanism

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