不同抗菌药对预防腹膜前间隙无张力疝修补术切口感染的临床效果分析

程永锋

（西安医学院第一附属医院沣东医院外科，陕西 西安，710086）

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摘要：

目的 评价预防性使用不同抗菌药物对腹膜间隙无张力疝修补手术切口部位感染的临床效果。方法 选择于我院行腹 膜前间隙无张力疝修补术的80 例腹股沟疝气患者，将其随机分为对照组和试验组。试验组共60 例患者，按术前30 min 所 给药物不同分为氨苄西林、阿莫西林、舒巴坦和头孢替安组，每组15 例；对照组共20 例患者，未预防性地应用任何抗菌药 物。统计手术后3 d 内各组患者术后感染情况、白细胞计数和中性粒细胞比例，记录患者术后切口愈合时间和住院时间。结果 对照组、氨苄西林、阿莫西林、舒巴坦和头孢替安组术后手术部位感染率分别为10.00%，0.00%，6.67%，0.00%和6.67%。对 照组与试验组患者及试验组内四组患者的白细胞计数、中性粒细胞比例、患者伤口愈合时间及住院时间比较，差异无统计学 意义（P>0.05）。结论 对行腹膜前间隙无张力疝修补术的腹股沟疝气患者预防性给予不同抗菌药物，其预防感染的临床效果 不显著，并不能明显促进伤口的愈合或降低感染率。

关键词：手术部位感染；腹膜前间隙无张力疝修补术；抗菌药物

中图分类号：R656.21文献标志码：A文章编号：2096-1413(2017)35-0052-02

Clinical analysis of different antimicrobial agents on the prevention of incision infection in tension-free hernia

repair of preperitoneal gap
CHENG Yong-feng
(Surgery Department, Fengdong Hospital, the First Affiliated Hospital of Xi``an Medical University, Xi``an 710086, China)

ABSTRACT: Objective To evaluate the clinical effect of different antimicrobial agents on the prevention of incision infection in anterior peritoneal tension-free hernia repair. Methods Eighty patients with inguinal hernia treated with anterior peritoneal tension-free hernia repair in our hospital were selected and randomly divided into control group and experimental group. Sixty cases of patients were enrolled in the experimental group and divided into ampicillin group, amoxicillin group, sulbactam group and cefotiam group according to different drugs they used at 30 min before surgery, with 15 cases in each group. While another 20 cases of patients who received no antibiotics treatment were enrolled in the control group. The postoperative infection, leucocyte count and neutrophil ratio of each group were statistically analyzed, and the incision healing time and hospitalization time of the patients were recorded. Results The postoperative infection rate of surgical site in the control group, ampicillin group, amoxicillin group, sulbactam group and cefotiam group were respectively 10.00%, 0.00%, 6.67%, 0.00% and 6.67%. There were no significant differences in white blood cell count, neutrophil ratio, wound healing time and length of hospital stay between the control group and the experimental group, and between the four groups of experimental groups (P>0.05). Conclusion The clinical effect of different antimicrobial agents in anterior peritoneal tension-free hernia repair to prevent infection is not significant, and prophylactic using of antimicrobial drugs can not significantly promote the wound healing or reduce the infection rate.
KEYWORDS: surgical site infection; anterior peritoneal tension-free hernia repair; antibacterial drugs

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