血清GDF-15mRNA与大肠癌患者病理特征的关系

郭玲1 ，袁亚迎1，田立1，朱小燕2

（1. 陕西省咸阳市第一人民医院，陕西 咸阳，712000；2.甘肃省平凉市泾川县人民医院，甘肃 平凉，744300）

浏览次数：96次 下载次数：350次

摘要：

目的 探讨血清生长分化因子-15（GDF-15）的mRNA 水平与大肠癌患者病理特征的关系。方法 选择70 例于我院采取 手术治疗的大肠癌患者为研究对象，并收集大肠癌患者癌组织切除标本，所有癌组织标本均经病理确诊。分析大肠癌患者各 病理特征与GDF-15 表达率的关系。结果 GDF-15 在大肠癌患者中的阳性表达率为72.86%。GDF-15 的阳性表达率与大肠 癌患者性别、年龄、肿瘤发生部位、组织学类型、肉眼分型比较，无显著差异（P>0.05）。低分化、有淋巴结转移及C、D 期大肠癌 患者GDF-15 的阳性表达率分别高于高、中分化、无淋巴结转移及A、B 期大肠癌患者，差异有统计学意义（P<0.05）。结论 血清GDF-15 mRNA 水平可反映肿瘤恶性程度、分化程度及是否存在淋巴结转移，在大肠癌的发生、发展中起重要作用，对临 床诊断及治疗具有一定的指导意义。

关键词：GDF-15；mRNA；大肠癌；病理特征

中图分类号：R735.34文献标志码：A文章编号：2096-1413(2017)35-0016-02

Relationship between serum GDF-15 mRNA and pathological features in patients with colorectal cancer
GUO Ling 1, YUAN Ya-ying 1, TIAN Li 1, ZHU Xiao-yan 2
(1. the First People``s Hospital of Xianyang City, Xianyang 712000; 2. People``s Hospital of Jingchuan County,
Pingliang 744300, China)

ABSTRACT: Objective To investigate the relationship between serum GDF-15 mRNA and pathological features in patients with colorectal cancer. Methods Seventy cases of patients with colorectal cancer who underwent surgical treatment in our hospital were enrolled in this study. Colorectal cancer tissue specimens of patients were collected and confirmed by pathology. The relationship between the serum GDF-15 expression and pathological features were analyzed. Results The positive expression rate of serum GDF-15 in patients with colorectal cancer was 72.86%. The positive expression rate of serum GDF-15 was not associated with sex, age, tumor location, histological type and macroscopic classification (P>0.05).The positive expression rates of GDF-15 in patients with low differentiation, lymph node metastasis and C, D stage in colorectal cancer were higher than those of high or middle differentiation, without ymph node metastasis and A, B stage in colorectal cancer (P<0.05). Conclusion The level of serum GDF-15 mRNA can reflect the degree of malignancy, differentiation and lymph node metastasis, which may play an important role in the occurrence and development of colorectal cancer. It has certain guiding significance for clinical diagnosis and treatment.
KEYWORDS: GDF-15; mRNA; colorectal cancer; pathological characteristic

参考文献：
[1] 王秀丽,芦桂芝,张慧琳,等.大肠癌患者心理一致感及其影响因素的研究进展[J].现代临床护理,2016,15(10):71-76.
[2] 申力,翁晓兰,曹建春,等.基于大肠癌早期筛查的中医体质类型分布规律研究[J].中华中医药杂志,2015,30(8):2914-2916.
[3] 李记彬,胡秀芬,刘放,等.大肠癌根治术腹腔镜手术与开腹手术长期疗效和安全性的比较[J].河北医学,21(2):210-212.
[4] 许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231.
[5] 杨静,姜波,海静,等.结肠癌转移相关基因1 和肝细胞生长因子受体蛋白表达与宫颈癌盆腔淋巴结转移相关性分析[J].中国妇幼保健,2016,31(4):838-841.
[6] 李倩,郝志明.生长分化因子11: TGF-茁 超家族的新成员[J].生物化学与生物物理进展,2015,42(7):616-623.
[7] 刘雅东,富路,刘佳,等.生长分化因子-15 在急性冠脉综合征中的 临床研究[J].现代生物医学进展,2015,15(2):391-393.
[8] 牛贝贝,田瑛.GDF15 在卵巢肿瘤中的研究进展[J].中国妇幼保健,2015,30(15):2473-2476.
[9] URAKAWA N,UTSUNOMIYA S,NISHIO M,et al.GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways [J].Lab Invest,2015,95(5):491-503.
[10] 黎晔,陈勍.GDF-15 在宫颈鳞状细胞癌中的表达及意义[J].实用 医学杂志,2013,29(24):4034-4036.
[11] GUIDOBONI M,GAF R,VIEL A,et al.Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis[J].Am J Pathol,2001,159(1):297-304.