腹腔镜手术联合GnRHa或孕三烯酮治疗子宫内膜异位症的疗效对比

刘娟弟，邓晓红，何菊仙，郝媛

（西北妇女儿童医院，陕西 西安，710061）

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摘要：

目的 研究腹腔镜手术联合GnRHa或孕三烯酮治疗子宫内膜异位症（EM）的疗效。方法 选择我院收治的80例EM患者作为研究对象，随机抽签分为对照组和观察组，各40例。所有患者均接受腹腔镜手术治疗，术后观察组行GnRHa治疗，对照组行孕三烯酮干预。比较两组患者的临床治疗效果、妊娠、复发情况及药物不良反应发生情况。结果 观察组显效率高于对照组（P<0.05）。观察组患者用药不良反应总发生率为17.50%（7/40），低于对照组的40.00%（16/40）（χ2=4.943，P=0.026）。观察组患者2年内总复发率为10.00%，明显低于对照组的40.00%（χ2=9.600，P=0.002）。观察组2年妊娠总成功率为32.50%，高于对照组的10.00%（χ2=6.050，P=0.014）。结论 腹腔镜手术联合GnRHa 用于EM患者较孕三烯酮效果更为显著，有助于控制复发。Ⅰ、Ⅱ期患者术后半年应用GnRHa 有助于提高妊娠成功率。

关键词：子宫内膜异位症；腹腔镜；GnRHa；孕三烯酮

中图分类号：R713文献标志码：A文章编号：2096-1413(2017)31-0086-02

Effect comparison of laparoscopic surgery combined with GnRHa or gestrinone in the treatment of endometriosis
LIU Juan-di, DENG Xiao-hong, HE Ju-xian, HAO Yuan


(Northwest Women and Children Hospital, Xi``an 710061, China)

ABSTRACT: Objective To study the effect of laparoscopic surgery combined with GnRHa or gestrinone in the treatment of endometriosis (EM). Methods Eighty EM patients in our hospital were randomly divided into control group and observation group, with 40 patients in each group. All the patients underwent laparoscopic surgery, then the observation group was treated with GnRHa, and the control group was treated with gestrinone. The clinical treatment effects, pregnancy recurrence and drug adverse reactions were compared in the two groups. Results The effective rate of the observation group was higher than that of the control group (P<0.05). The overall incidence rate of drug adverse reactions in the observation group was 17.50% (7/40), which was lower than 40.00% (16/40) of the control group ( χ2=4.943, P=0.026). The total recurrence rate in the observation group was 10.00% within 2 years, which was lower than 40.00% in the control group ( χ2=9.600, P=0.002). The total pregnancy success rate in 2 years of the observation group was 32.50%, which was higher than 10.00% of the control group ( χ2=6.050, P=0.014). Conclusion Laparoscopic surgery combined with GnRHa has better effect on EM patients than gestrinone, which can help to control the recurrence. GnRHa used in I-II EM patients after operation of half one year is helpful to improve the success rate of pregnancy.
KEYWORDS: endometriosis; laparoscopic; GnRHa; gestrinone

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