2017 年9 月 盐酸右美托咪定应用于重症监护患者的镇静、镇痛效果

王宏斌

（陕西省宝鸡市人民医院重症医学科，陕西 宝鸡，721000）

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摘要：

目的 探讨盐酸右美托咪定应用于重症监护患者的镇静、镇痛效果。方法 选取2014年10月至2016年1月我院收治的重症监护患者80例，随机分为对照组及观察组，各40例。对照组患者给予咪达唑仑进行镇静和镇痛，观察组患者采用盐酸右美托咪定进行镇静和镇痛。比较两组患者的镇静程度、VAS评分、唤醒时间、机械通气时间、血压、心率、呼吸频率、不良反 应发生情况。结果 治疗后，两组患者镇静程度及VAS 评分明显优于治疗前，且观察组的上述指标明显优于对照组（P<0.05）。两组患者的机械通气时间、血压、呼吸频率比较，差异无统计学意义（P>0.05）；两组患者唤醒时间及心率比较，差异具有统计学意义（P<0.05）。观察组患者的不良反应发生率明显低于对照组（P<0.05）。结论 对重症监护患者采用盐酸右美托咪定进行镇静和镇痛，临床效果显著，安全性高，能够快速降低患者疼痛程度，不会影响患者血流动力学，并发症及不良反应发生率较低，值得临床推广应用。

关键词：重症监护患者；盐酸右美托咪定；镇静；镇痛

中图分类号：R614文献标志码：A文章编号：2096-1413(2017)27-0020-02

Sedation and analgesia effects of dexmedetomidine in intensive care unit patients
WANG Hong-bin
(Department of ICU, Baoji People``s Hospital, Baoji 721000, China)

ABSTRACT: Objective To explore the sedation and analgesia effects of dexmedetomidine in intensive care unit patients. Methods Eighty intensive care unit patients admitted in our hospital from October 2014 to January 2016 were selected and randomly divided into control group and observation group, with 40 cases in each group. The control group received midazolam for sedation and analgesia, and the observation group accepted dexmedetomidine for sedation and analgesia. The sedation degree, VAS scores, wake-up time, mechanical ventilation time, blood pressure, heart rate, respiratory rate and adverse reactions were compared between the two groups. Results After treatment, the sedation degree and VAS scores of the two groups were better than those before treatment, and those of the observation group were better than the control group (P<0.05). There were no significant differences in mechanical ventilation time, blood pressure and respiratory rate between the two groups (P>0.05), but the wake-up time and heart rate had significant differences between the two groups (P<0.05).The adverse reactions rates of the observation group were higher than those of the control group (P<0.05). Conclusion The sedation and analgesia effects of dexmedetomidine in intensive care unit patients are significant, which has high safety. It can rapidly reduce the pain of patients, and can not affect the hemodynamics, and the incidences of complications and adverse reactions are low. It is worthy of clinical application and promotion.
KEYWORDS: intensive care unit patients; dexmedetomidine; sedation; analgesia

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