冠心病合并脑梗死患者应用阿托伐他汀与苯磺酸氨氯地平联合治疗的临床疗效分析

张万玲，李红梅，向海荣

（西安医学院附属北方医院心内科，陕西 西安，710043）

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摘要：

目的 探讨阿托伐他汀与苯磺酸氨氯地平联合治疗冠心病合并脑梗死患者的临床疗效、不良反应发生情况，以及对血脂、神经功能的影响。方法 本研究对象为2015 年1月至2016年1月我院收治的冠心病合并脑梗死患者，共计96例。采用随机数字表法将其分为研究组与对照组，各48例。对照组患者采用苯磺酸氨氯地平治疗，研究组在此基础上应用阿托伐他汀治疗，比较两组患者治疗总有效率、治疗前、后血脂水平、ESS 评分及治疗期间的药物副作用情况。结果 研究组患者治疗总有效率为91.67%，显著高于对照组的75.00%（P<0.05）；研究组治疗后TC、LDL-C 与TG 的水平分别为（4.74±1.22）mmol/L、（3.15±1.22）mmol/L、（1.05±1.52）mmol/L，分别低于对照组治疗后的（5.24±1.05）mmol/L、（3.88±1.20）mmol/L、（1.50±1.22）mmol/L （P<0.05）；研究组治疗后ESS评分为（85.6±10.5）分，明显高于对照组的（72.5±10.6）分（P<0.05）；两组治疗期间的药物不良反应对比差异无统计学意义（P>0.05）。结论 冠心病合并脑梗死患者应用阿托伐他汀与苯磺酸氨氯地平联合治疗效果较好，可以有效改善患者的心肌功能，降低血脂水平，促进神经功能恢复，安全可靠，适于临床应用与推广。

关键词：冠心病；脑梗死；阿托伐他汀；苯磺酸氨氯地平

中图分类号：R541.4文献标志码：A文章编号：2096-1413(2016)27-0004-03

Clinical efficacy analysis of atorvastatin and amlodipine besylate on coronary heart disease complicated with cerebral infarction
ZHANG Wan-ling, LI Hong-mei, XIANG Hai-rong
(Department of Cardiology, Xi`an Medical University Affiliated Northern Hospital, Xi`an 710043, China)

ABSTRACT: Objective To evaluate the clinical efficacy, adverse reactions, as well as effects on blood lipids and neurological function of atorvastatin and amlodipine besylate in the treatment of coronary heart disease complicated with cerebral infarction. Methods A total of 96 cases with coronary heart disease complicated with cerebral infarction admitted in our hospital from January 2015 to January 2016 were selected and divided into study group and control group according to random number table, with 48 cases in each group. The control group accepted amlodipine besylate, while the study group received atorvastatin on the basis of the control group, then the total effective rate, the levels of lipids, ESS scores and drug adverse reactions in the two groups were compared. Results The total effective rate of the study group was 91.67%, which was significantly higher than 75.00% of the control group (P<0.05); the levels of TC, LDL-C and TG group levels after treatment were (4.74±1.22) mmol/L, (3.15±1.22) mmol/L and (1.05±1.52) mmol/L respectively in the study group, which were significantly lower than (5.24±1.05) mmol/L, (3.88±1.20) mmol/L and (1.50±1.22) mmol/L in the control group after treatment (P<0.05); the ESS score of the study group was (85.6±10.5), which was significantly higher than (72.5±10.6) (P<0.05); the difference of drug adverse events during the treatment between the two groups was not significant (P >0.05). Conclusion For patients with coronary heart disease complicated with cerebral infarction, atorvastatin and amlodipine besylate combination therapy can effectively improve cardiac function of patients, reduce blood lipid levels and promote recovery of neurological function, which is safe and reliable, and is suitable for clinical application and promotion.
KEYWORDS: coronary heart disease; cerebral infarction; atorvastatin; amlodipine besylate

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