溃疡性结肠炎应用美沙拉嗪与柳氮磺吡啶治疗的效果比较

党静

（陕西省咸阳市三原县医院消化内科，陕西 咸阳，713800）

浏览次数：248次 下载次数：289次

摘要：

目的 比较溃疡性结肠炎应用美沙拉嗪与柳氮磺砒啶治疗的临床效果。方法 选取我院2010年2月至2015年2月收治的溃疡性结肠炎患者100例为研究对象，按照随机数字表法分为对照组和试验组，各50例。对照组患者采用柳氮磺砒啶进行治疗，试验组患者采用美沙拉嗪进行治疗。比较两组患者的治疗效果及治疗前、后的症状评分。结果 试验组治疗总有效率明显高于对照组，差异具有统计学意义（P<0.05）。治疗前，两组患者的症状积分比较，差异无统计学意义（P>0.05）；治疗后，两组患者的症状积分明显优于治疗前，且试验组明显优于对照组，差异具有统计学意义（P<0.05）。结论 美沙拉嗪治疗溃疡性结肠炎的效果显著，能明显改善患者的症状积分，具有较高临床推广价值。

关键词：溃疡性结肠炎；美沙拉嗪；柳氮磺砒啶

中图分类号：R574.62文献标志码：A文章编号：2096-1413(2017)16-0060-02

Effect comparison of mesalazine and sulfasalazine in the treatment of ulcerative colitis
DANG Jing
(Department of Gastroenterology Medicine, Sanyuan County Hospital, Xianyan 713800, China)

ABSTRACT: Objective To compare the clinical effects of mesalazine and sulfasalazine in the treatment of ulcerative colitis. Methods One hundred cases of patients with ulcerative colitis admitted in our hospital from February 2010 to February 2015 were selected as the study objects. All the patients were divided into control group and experimental group according to the digital random method, with 50 cases in each group. The control group was treated with sulfasalazine, and the experimental group adopted mesalazine. The clinical effects and symptom scores before and after treatment of the two groups were compared. Results The total effective rate of the experimental group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference on symptom scores between the two groups (P>0.05). After treatment, the symptom scores of the two groups were better than those before treatment, and the symptom scores of the experimental group were significantly better than those of the control group, the differences were statistically significant (P<0.05). Conclusion Mesalazine in the treatment of ulcerative colitis has significant clinical effect, it can significantly improve the symptom scores of the patients, which has high clinical value.

KEYWORDS: ulcerative colitis; mesalazine; sulfasalazine

参考文献：
[1] 张振平,钟广时,邓裕朋.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎效果比较[J].中国实用医药,2016,11(3):17-19.
[2] 曾权祥,陈赞雄,吴振华,等.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效对比[J].深圳中西医结合杂志,2015,25(23):94-96.
[3] 林贵德,刘婵,马东升.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效和安全性分析[J].临床医学工程,2016,23(2):227-228.
[4] 张建立,卞孝平,辛克北,等.美沙拉嗪联合柳氮磺吡啶治疗溃疡性结肠炎的临床观察[J].中国实用医药,2016,11(15):140-142.
[5] 高新英.美沙拉嗪缓释颗粒及柳氮磺吡啶治疗活动期轻、中度溃疡性结肠炎的疗效和不良反应比较[J].医疗装备,2016,29(10):20-21.
[6] 卢俊林.研究美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床有效性[J].中国实用医药,2016,11(23):148-149.
[7] 柳汝明,吴斌,赵雨晋,等.美沙拉嗪与柳氮磺吡啶比较治疗溃疡性结肠炎疗效与安全性的系统评价[J].中国循证医学杂志,2011,11(2):181-186.
[8] 吴小玲,何义波,吴瑜梅.柳氮磺吡啶片联合中药保留灌肠治疗溃疡性结肠炎的效果观察[J].中国当代医药,2015,22(26):158-160.
[9] 成龙,龚磊,王凯彬.美沙拉嗪在轻中度溃疡性结肠炎治疗中的临床疗效及安全性[J].中国医学工程,2013,21(12):63,66.