拉贝洛尔辅助治疗重度妊娠高血压的疗效和安全性分析

任晓华，南艳玲

（陕西省子长县人民医院妇产科，陕西 延安，717300）

浏览次数：108次 下载次数：315次

摘要：

目的 探讨拉贝洛尔辅助治疗重度妊娠高血压的疗效和安全性。方法 选取我院收治的重度妊高征患者58例为研究对象，按入院时间将患者分为对照组和观察组，各29例。对照组患者采用硫酸镁治疗，观察组在对照组基础上加用拉贝洛尔治疗，比较两组患者的临床效果、治疗前后24 h尿蛋白、平均动脉压水平及并发症发生情况。结果 治疗后，两组患者的24h尿蛋白、平均动脉压水平明显优于治疗前，且观察组明显优于对照组（P<0.05）。观察组总有效率为96.6%，明显高于对照组的 86.2%（P<0.05）。观察组并发症发生率为6.9%，明显低于对照组的24.1%（P<0.05）。结论 重度妊高征患者采用拉贝洛尔辅助硫酸镁进行治疗，临床效果理想，并发症发生率低。

关键词：重度妊娠高血压；安全性；拉贝洛尔

中图分类号：R714.246文献标志码：A文章编号：2096-1413(2017)16-0058-02

Effect and safety of labetalol in the adjuvant treatment of severe pregnancy-induced hypertension
REN Xiao-hua, NAN Yan-ling
(Department of Obstetrics and Gynecology, People`s Hospital of Zichang County, Yan`an 717300, China)

ABSTRACT: Objective To investigate the effect and safety of labetalol in the adjuvant treatment of severe pregnancy-induced hypertension. Methods Fifty-eight cases of patients with severe pregnancy-induced hypertension admitted in our hospital were selected and divided into control group and observation group according to the admission order, with 29 cases in each group. The control group was treated with magnesium sulfate, and the observation group accepted labetalol on the basis of the control group. The clinical effects, levels of 24 h proteinuria and mean arterial pressure before and after treatment of the two groups were compared. Results After treatment, the levels of 24 h proteinuria and mean arterial pressure of the two groups were better than those before treatment, and those of the observation group were better than the control group (P<0.05). The total effective rate of the observation group was 96.6%, which was higher than 86.2% of the control group (P<0.05). The incidence rate of complications of the observation group was 6.9%, which was lower than 24.1% of the control group (P<0.05). Conclusion Labetalol in the adjuvant treatment of severe pregnancy -induced
hypertension has significant clinical effect, which has low incidence rate of complications.
KEYWORDS: severe pregnancy-induced hypertension; safety; labetalol

参考文献：
[1] 姜丽,姜平,曲文玉,等.拉贝洛尔辅助治疗重度妊娠高血压疾病的疗效和安全性分析[J].当代医学,2016,22(8):139-140.
[2] 沈方方.拉贝洛尔联合硫酸镁治疗重度妊娠高血压疾病的临床观察[J].长江大学学报:自然版,2011,8(3):150-151,154.
[3] 王红丽.拉贝洛尔联合硫酸镁治疗中重度妊娠高血压综合征疗效观察[J].临床合理用药杂志,2013,6(19):73-74.
[4] 张力敏.拉贝洛尔联合硫酸镁治疗重度妊娠高血压疗效及对分娩结局的影响[J].中国处方药,2015,13(1):121-122.
[5] 赵卫东,韩庆丰,刘立敏,等.拉贝洛尔联合硫酸镁治疗重度妊娠高血压疾病疗效观察[J].现代中西医结合杂志,2013,22(14):1532-1534.