益生菌联合可溶性膳食纤维对溃疡性结肠炎的疗效观察

刘鹏飞，薛顺和

（延安大学附属医院，陕西 延安，716000）

浏览次数：133次 下载次数：365次

摘要：

目的 观察益生菌与可溶性膳食纤维联合治疗溃疡性结肠炎的效果。方法 选择我院收治的64例轻中度溃疡性结肠炎患者，随机分为对照组和观察组，各32例，均给予口服美沙拉嗪，治疗2周后病情未向重度转化，对照组加服益生菌，观察组在对照组基础上口服可溶性膳食纤维，观察两组患者临床治疗效果、肠镜检查效果及不良反应发生情况。结果 治疗8周后，观察组治疗总有效率为94.26%，明显高于对照组的74.30%，差异有统计学意义（P<0.05）。观察组结肠镜复查总有效率为 93.75%，明显高于对照组的71.88%，差异有统计学意义（P<0.05）。观察组不良反应发生率显著低于对照组，差异有统计学意 义（P<0.05）。结论 使用益生菌联合可溶性膳食纤维治疗溃疡性结肠炎疗效显著，且安全性高，值得临床推广和应用。

关键词：溃疡性结肠炎；益生菌；可溶性膳食纤维

中图分类号：R574.62文献标志码：A文章编号：2096-1413(2017)16-0015-03

Effect observation of probiotics combined with soluble dietary fiber on ulcerative colitis
LIU Peng-fei, XUE Shun-he
(Yan`an University Affiliated Hospital, Yan`an 716000, China)

ABSTRACT: Objective To observe the effect of probiotics and soluble dietary fiber on ulcerative colitis. Methods Sixty-four patients diagnosed with mild to moderate ulcerative colitis in our hospital were randomly divided into control group and observation group, with 32 cases in each group. After 2 weeks of treatment with mesalazine, patients` condition had not changed to severe. Then the control group added probiotics, and the observation group added oral probiotics soluble dietary fiber on the basis of the control group. The clinical curative effect, the effect of colonoscopy and the occurrence of adverse reaction of the two groups was observed. Results After 8 weeks of treatment, the total effective rate was 94.26% in the observation group, which was significantly higher than 74.30% of the control group, the difference was statistically significant (P<0.05). The total effective rate of colonoscopy was 93.75% in the observation group, which was significantly higher than 71.88% of the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion Probiotics combined with soluble dietary fiber has significant curative effect in the treatment of ulcerative colitis, with high safety, which is worthy of clinical promotion and application.
KEYWORDS: ulcerative colitis; probiotics; soluble dietary fiber

参考文献：
[1] 钟雄利,谭小燕,许超贵,等.炎症性肠病治疗中益生菌联合美沙拉嗪的应用效果探讨[J].中国实用医药,2015,10(14):189-190.
[2] SANDERS ME,GUARNER F,GUERRANT R,et al.An update on the useand investigation of probiotics in health and disease[J].Gut,2013,62 (5):787-796.
[3] DE GREEF E,VANDENPLAS Y,HAUSER B,et al.Probiotics and IBD[J].Acta Gastroenterol Belg,2013,76(1):15-19.
[4] 胡品津.炎症性肠病诊断与治疗的共识意见解读(2012 年·广州)[J].胃肠病学,2012,17(12):709-711.
[5] 曹婷,曲波,李惠.炎症性肠病发病机制研究进展[J].胃肠病学,2016,21(9):569-572
[6] 张洁.炎症性肠病临床治疗中益生菌与美沙拉嗪联合治疗的效果观察[J].医药前沿,2014,4(27):7-8.
[7] 张静之,包春辉,施征,等.肠道菌群参与炎症性肠病发病机制研究新进展[J].世界华人消化杂志,2016,24(33):4505-4513.
[8] 马淑荣,沈可欣,周长玉,等.益生菌在炎症性肠病中的作用观察[J].中国实验诊断学,2013,17(1):150-152.
[9] 周正,马婷,冯澜,等.马齿苋多糖对溃疡性结肠炎小鼠肠道菌群及血内毒素的影响[J].中国微生态学杂志,2014,26(6):646-648.
[10] 李宁,蒋小华,朱维铭.含膳食纤维和中链三酰甘油的肠内营养制剂在胃癌术后的应用[J].肠外与肠内营养,2004,11(3):158-160.
[11] LU L,WALKER WA.Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium[J].Am J Clill Nutr,2001,73 (6):1124-1130.
[12] JOO E,YAMANE S,HAMASAKI A,et al.Enteral supplement enriched with glutamine，fiber，and oligosaccharide attenuates experimental colitis in mice[J].Nutrition,2013,29(3):549-555.