北京市“渐冻症”发病率及影响因素分析研究

周晟瀚员 ，钱思霖1 ，常文兵1 ，王丽平2

（1.北京航空航天大学可靠性与系统工程学院，北京，1001912；2.北京大学第三医院神经内科，北京，100191）

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摘要：

目的 分析2010—2015年北京市“渐冻症”发病率及影响因素，为本地医疗资源配置和相关政策决策提供参考依据。 方法 结合北京大学第三医院2010—2015年的“渐冻症”患者统计信息和同期内北京东方丝雨渐冻人罕见病关爱中心的自我普查报告两份数据，证明样本分布的一致性，从而估计出北京市患者数，结合人口学资料，开展北京市“渐冻症”患者的发病率及影响因素分析研究。结果 北京市2010—2015年“渐冻症”的年均发病率为2.708人/10万人，其中男性发病率为3.308人/10万人，女性2.069人/10万人，男女患者比例为1.698∶1；北京市“渐冻症”患者的年龄分布服从三参数的weibull分布，男性平均发病年龄53.89岁，女性平均发病年龄52.42岁。结论 北京市2010—2015年“渐冻症”患者的发病率相符于全球发病率的2 人/10万人~4人/10万人，男性发病率比女性发病率高，与国外研究结论一致。“渐冻症”发病率与年龄有关，在60岁之前，发病率随着年龄的增加而增加，60岁之后，发病率逐渐降低，在年龄增长到一定岁数后发病风险下降，患者发病年龄主要集中在30~65岁。

关键词：渐冻症；发病率；影响因素；医疗数据处理

中图分类号：R744文献标志码：A文章编号：2096-1413(2017)16-0001-05

Research on the incidence rate of amyotrophic lateral sclerosis (ALS) and its influence factors in Beijing
ZHOU Sheng-han 1, QIAN Si-lin 1, CHANG Wen-bing 1, WANG Li-ping 2
(1. School of Reliability and Systems Engineering of Beihang University, Beijing 1001912; 2. Department of Neurology, Peking University Third Hospital, Beijing 100191, China)

ABSTRACT: Objective To analyze the incidence of amyotrophic lateral sclerosis (ALS) and its influence factors, so as to provide reference for local medical resource allocation and related policy decision. Methods The two self-census report data of ALS patients with Peking University Third Hospital from 2010 to 2015 and Oriental Rain ALS Care over the same period proved the consistency of the sample distribution, and were used to estimate the incidence of ALS in Beijing. Combined with demographic data, to analyze the morbidity and influence factors of ALS patients in Beijing. Results The average annual incidence rate of ALS in Beijing from 2010 to 2015 was 2.708/10 million, including male incidence rate of 3.308 people/10 million, female 2.069 people/10 million, the ratio of male to female is 1.698∶1. The age distribution of ALS patients in Beijing obeyed the weibull distribution of three parameters. The average age of males was 53.89 years old and the average age of females was 52.42 years old. Conclusion The morbidity rate of the patients in Beijing from 2010 to 2015 was consistent with the global incidence rate of 2 people/10 million to 4 people/10 million. The incidence of males was higher than that of females and was consistent with the conclusion of foreign studies. The incidence of ALS is age-related. Before the age of 60, the morbidity increases with age. After 60 years of age, the morbidity gradually reduces and the risk of disease reduces after age increaseing to a certain degree. The age of patients is mainly concentrated in the 30 to 65 years old.
KEYWORDS: amyotrophic lateral sclerosis (ALS); incidence rate; influence factor; medical data processing

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