拉氧头孢治疗大叶性肺炎的疗效及预后分析

白玉

（西安市长安区人民医院，陕西 西安，710100）

浏览次数：201次 下载次数：432次

摘要：

目的 探讨拉氧头孢治疗大叶性肺炎的疗效及预后。方法 将160例大叶性肺炎患者随机分为阿莫西林组与拉氧头孢 组，各80例，连续治疗2周后比较两组的肺部啰音消失时间、止咳时间、肺部影像学恢复时间、住院时间及不良反应发生率， 并比较两组患者治疗前后CRP、ESR水平及中性粒细胞分类。结果 拉氧头孢组的肺部啰音消失时间、止咳时间、住院时间均明显短于阿莫西林组（P<0.05）。治疗前，两组患者的CRP、ESR水平及中性粒细胞分类比较无明显差异（P>0.05）；治疗后，两组的CRP、ESR水平及中性粒细胞分类均较治疗前降低，但拉氧头孢组的降低幅度更大，均明显低于阿莫西林组（P<0.05）。 两组不良反应均轻微，组间比较，无明显差异（P>0.05）。结论 拉氧头孢治疗大叶性肺炎的疗效确切，可更快改善临床症状，且不良反应轻微，临床应用价值大。

关键词：拉氧头孢；大叶性肺炎；阿莫西林

中图分类号：R563.1文献标志码：A文章编号：2096-1413(2017)11-0014-02

Efficacy and prognosis of moxalactam on patients with lobar pneumonia
BAI Yu
(People's Hospital of Chang'an District, Xi'an 710100, China)

ABSTRACT: Objective To explore the efficacy and prognosis of moxalactam on patients with lobar pneumonia. Methods One hundred cases of patients with lobar pneumonia were randomly divided into amoxicillin group (n=80) and moxalactam group (n=80). After 2 weeks of continuous treatment, the time of pulmonary rales disappearing, cough relieving, pulmonary imaging recovering, hospitalization and incidence of adverse reaction were compared and the levels of CRP, ESR and neutrophil percentages were detected in the two groups. Results The time of pulmonary rales disappearing, cough relieving and hospitalization in the moxalactam group were shorter than those of the amoxicillin group (P <0.05). Before treatment,there were no significant difference in the levels of CRP, ESR and neutrophil percentages; After treatment, the levels of CRP, ESR and neutrophil percentages decreased in the two groups, and those of the moxalactam group were lower than the amoxicillin group (P<0.05). The adverse reaction of two groups were mild, and there was no significant difference between the two groups (P>0.05). Conclusion Moxalactam has obvious curative effect on patients with lobar pneumonia, which can be faster to improve clinical symptoms, and has mild adverse reactions, it has clinical application value.
KEYWORDS: moxalactam; lobar pneumonia; amoxicillin

参考文献：
[1] 刘裕忠,刘军.阿莫西林与头孢哌酮治疗大叶性肺炎疗效比较[J]. 吉林医学,2010,31(30):5330.
[2] 任蓉.盐酸头孢甲肟与阿奇霉素联合治疗儿童大叶性肺炎的疗效观察[J].中国医药导刊,2013,11(9):1500-1501.
[3] ITO A,TATSUMI Y,WAJIMA T,et al.Potent antibacterial activities of latamoxef (moxalactam) against ESBL producing Enterobacteriaceae analyzed by Monte Carlo simulation[J].Jpn J Antibiot,2014,67(2):109-122.
[4] 陶旭云,屈弘宇.小剂量甲泼尼龙三联疗法治疗儿童难治性大叶性肺炎支原体肺炎的临床疗效及安全性研究[J].实用心脑肺血管病杂志,2015,23(9):74-76.
[5] 燕海英,杨阳,腾鸿,等.注射用盐酸头孢吡肟与硫酸头孢噻利治疗中重度社区获得性肺炎的临床疗效分析[J].西部医学,2016,28(4):483-486.
[6] 贺霞,周庄,张琰,等.头孢哌酮/舒巴坦钠联合米诺环素治疗老年泛耐药鲍曼不动杆菌肺炎的疗效观察[J].检验医学与临床,2015,12(13):1876-1877.
[7] 丁屹.熊去氧胆酸治疗妊娠期肝内胆汁淤积症的疗效及对围生儿预后的影响分析[J].中国妇幼保健,2014,29(5):710-711.