孟鲁司特钠对慢阻肺患者肺功能及Th1、Treg的影响分析
高仑，孙秀娥
（榆林市第一医院，陕西 榆林，718000）
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摘要：
目的 分析孟鲁斯特钠对慢阻肺患者肺功能及Th1、Treg的影响。方法 选取慢阻肺患者64例，随机分为试验组（常规治疗+孟鲁司特钠）和对照组（常规治疗），比较两组患者的治疗效果。结果 与治疗前相比，两组患者治疗后的肺功能及血气指标均有显著改善，且试验组改善情况优于对照组（P<0.05）；两组患者治疗前、后的IFN-γ水平无明显变化（P>0.05），试验组患者的IL-10水平有显著升高（P<0.05）。结论 慢阻肺患者在常规治疗的基础上加用孟鲁司特钠，可以有效抑制炎症反应，调 节Th1/Treg平衡状态，改善肺通气。
关键词：孟鲁斯特钠；慢阻肺；肺功能；血气分析
中图分类号：R563.9文献标志码：A文章编号：2096-1413(2017)08-0008-02
Influence analysis of montelukast on lung function and Th1 and Treg in patients with chronic
obstructive pulmonary disease
GAO Lun, SUN Xiu-e
(the First Hospital of Yulin, Yulin 718000, China)
ABSTRACT: Objective To analyze the influence of montelukast treatment on lung function and Th1 and Treg in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty-four cases of patients with COPD were selected and randomly divided into experimental group (conventional treatment+montelukast) and control group (conventional treatment). The therapeutic effects of the two groups were compared. Results Compared with that before treatment, the lung function and blood gas results in the two groups improved significantly after treatment, and the improvement in the experimental group was greater than that in the control group (P<0.05). There was no significant change in IFN-γ level between the two groups before and after treatment (P>0.05), and the level of IL-10 in the experimental group was significantly higher (P<0.05).
Conclusion For patients with chronic obstructive pulmonary disease, montelukast on the basis of conventional therapy can effectively inhibit the inflammatory response, regulate the imbalance of Th1/Treg status, and improve lung ventilation.
KEYWORDS: montelukast; chronic obstructive pulmonary disease; pulmonary function; blood gas analysis
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