姑息性手术与介入治疗对肝癌患者预后的影响

魏辉，江静，刘金鹏，黄辉

（陕西中医药大学附属医院：1. 肿瘤四科；2.放疗科，陕西 咸阳，712000）

浏览次数：114次 下载次数：390次

摘要：

目的 探讨姑息性手术与介入治疗对肝癌患者预后的影响。方法 选取我院2010年1月至2013年1月收治的86例肝癌患者为研究对象，根据不同的治疗方法分为对照组和研究组，对照组43例患者给予姑息性手术治疗，研究组43例患者在对照组的基础上给予介入治疗，观察两组患者的生存时间及生存质量。结果 入选的86例患者均获得随访，随访时间2~73个月，对照组1年生存率为79.07%，3年生存率为48.84%，5年生存率为25.58%，平均生存期为31.28个月。研究组1年生存 率为86.05%，3年生存率为60.47%，5年生存率为39.53%，平均生存期为40.13个月。两组患者的生存率及平均生存期比 较差异显著（P<0.05）。两组患者治疗后的各项生存质量评分较治疗前均有所改善（P<0.05），研究组改善程度显著优于对照组（P<0.05）。结论 介入治疗联合姑息性治疗相较于单一介入治疗能够明显延长患者的生存时间，改善患者的生活质量。

关键词：姑息性手术；介入治疗；肝癌；生存时间

中图分类号：R735.7文献标志码：A文章编号：2096-1413(2017)05-0016-02

Effect of palliative surgery and interventional therapy on the prognosis

of patients with hepatocellular carcinoma
WEI Hui 1, JIANG Jing 1, LIU Jin-peng 1, HUANG Hui 2
(1. Department of 4th Oncology; 2. Department of Radiotherapy, the Affiliated Hospital of Shaanxi University

of Chinese Medicine, Xianyang 712000; China)

ABSTRACT: Objective To investigate the effect of palliative surgery and interventional therapy on the prognosis of patients with hepatocellular carcinoma (HCC). Methods Eighty-six patients with HCC from January 2010 to January 2013 in our hospital were selected and divided into control group and research group according to the different treatment methods. The control group (43 cases) received palliative surgery, while the research group received interventional therapy on the basis of the control group. The survival time and quality of life of the two groups were observed. Results All the patients (86 cases) were followed up for 2-73 months. In the control group, the survival rate of one year, three years and five years was 79.07%, 48.84% and 25.58% respectively, the average survival time was 31.28 months. In the research group, the survival rate of one year, three years and five years was 86.05%, 60.47% and 39.53% respectively, the average survival time was 40.13 months. The differences of the survival rate and average survival time between the two groups were statistically significant (P<0.05). After treatment, the life quality scores of the two groups were significantly improved than those before treatment (P<0.05), and the improvement degree of the study group was significantly better than that of the control group (P<0.05). Conclusion Palliative surgery combined with interventional therapy can obviously prolong the patients' sur-vival time, and improve the patients' quality of life.
KEYWORDS: palliative surgery; interventional therapy; hepatocellular carcinoma; survival time

参考文献：
[1] HU X,YANG X,HE Q,et al.Glyoxalase 1 is up-regulated in hepato- cellular carcinoma and is essential for HCC cell proliferation[J].Biotech-nol Lett,2014,36(2):257-263.
[2] 余子牛,鲁东,周春泽,等.原发性肝癌患者TACE治疗后预后和生存分析[J].安徽医科大学学报,2015,50(10):1515-1518.
[3] 刘静,朱伟.原发性肝癌合并门静脉癌栓的综合介入治疗[J].当代 医学,2013,19(5):16-17.
[4] 刘晓松.原发性肝癌姑息治疗不同手段的临床预后分析[D].长沙: 中南大学,2011.
[5] 刘穗玲.肝癌介入治疗患者应对方式、社会支持与生活质量的相关性研究[D].长沙:中南大学,2014.
[6] 雷振武.海藻酸钠微球加固栓塞用于肝癌介入治疗对患者预后情况及血清学指标的影响[J].中国现代医学杂志,2015,25(28):41-44.
[7] 马国霞.影响中晚期肝癌患者介入治疗预后的危险因素及干预对策[J].中国肿瘤临床与康复,2013,20(4):309-311.
[8] 黄忠光,吴荣兴,蒋绍香,等.102例肝癌患者介入治疗后生存情况及影响因素[J].实用癌症杂志,2013,28(6):725-727.
[9] 赵月皎,汤艳清,刘文中.不同术式喉癌患者136例术后心理状态分析[J].中国组织工程研究,2005,9(40):56-58.
[10] 马妮娜,张瑞雪.介入治疗和姑息性手术治疗对肝癌患者预后的影响比较[J].贵州医药,2014,38(9):796-797.
[11] 徐克育,黄约翰,陶崇林,等.手术切除与肝动脉介入栓塞化疗治疗原发性肝癌破裂出血比较及预后分析[J].肝胆胰外科杂志,2014,26(1):9-11.
[12] 管清龙,纪卫政,任伟新,等.肝癌介入治疗后血清缺氧诱导因子和血管内皮生长因子含量变化对预后的影响[J].介入放射学杂志,2014,23(2):142-146.