氯吡格雷治疗短暂性脑缺血发作的临床效果

李建凯，陈宝红

（西安市华山中心医院，陕西 西安，710043）

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摘要：

目的 探讨氯吡格雷联合阿司匹林治疗短暂性脑缺血发作患者的临床效果。方法 抽选短暂性脑缺血发作患者120例分为两组。对照组（60例）给予阿司匹林等常规治疗，观察组（60例）在对照组基础上口服氯吡格雷治疗，比较两组治疗效果， 以及治疗前后PT、APTT、FIB、PLT 等凝血功能指标。结果 观察组患者治疗有效率为93.33%，高于对照组患者的76.67%（P<0.05）。治疗后观察组患者的PT、APTT、FIB、PLT指标优于对照组（P<0.05）；随访期间，观察组复发率、发展为脑梗死率均低 于对照组（P<0.05）。结论 在阿司匹林基础上增加氯吡格雷能有效提升短暂性脑缺血的治疗效果，安全性高，值得推广。

关键词：氯吡格雷；短暂性脑缺血发作；凝血功能

中图分类号：R788.1文献标志码：A文章编号：2096-1413(2017)05-0012-02

The clinical effect of clopidogrel in the treatment of transient ischemic attack
LI Jian-kai, CHEN Bao-hong
(Central Hospital of Huashan, Xi'an 710043, China)

ABSTRACT: Objective To investigate the clinical effect of clopidogrel in the treatment of patients with transient ischemic attack. Methods One hundred and twenty cases of patients with transient ischemic attack were selected and divided into two groups. The control group (60 cases) was given conventional therapy such as aspirin, the observation group (60 cases) was given clopidogrel oral treatment on the basis of control group. The clinical effect and coagulation function indexes such as PT, FIB, PLT before and after treatment of two groups were compared. Results The total effective rate of the observation group was 93.33%, which was higher than 76.67% of the control group (P<0.05). After treatment, the levels of PT, APTT, FIB and PLT of the observation group were better than those of the control group (P<0.05). During follow-up visit, the recurrence rate and development rate of death of the observation group were better than those of the control group (P<0.05).Conclusion Adding clopidogrel on the basis of conventional therapy such as aspirin can effectively improve the clinical effect of transient ischemic attack. It has high safety and which is worthy of promotion in clinic.
KEYWORDS: clopidogrel; transient ischemic attack; coagulation function

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