强脉冲光联合吡美莫司乳膏治疗面部激素依赖性皮炎疗效观察

刘颖，仵宁

（咸阳市中心医院，陕西 咸阳，712000）

浏览次数：130次 下载次数：565次

摘要：

目的 评价强脉冲光联合吡美莫司乳膏对激素依赖性皮炎患者面部皮肤的治疗效果。方法 选取在我院皮肤科门诊就诊的激素依赖性皮炎患者60例，随机分为治疗组和对照组。治疗组（34例）进行强脉冲光联合吡美莫司乳膏治疗，强脉冲光每4周治疗1次，连续5次，吡美莫司乳膏每晚外用1次。对照组（26 例）单纯应用吡美莫司乳膏治疗，每晚1次，连续治疗5个 月。分别在治疗前、后对两组患者进行疗效评价。结果 治疗后两组主观体征和客观体征评分均较治疗前显著改善，差异均有统计学意义（P<0.05）。治疗组与对照组的主观体征有效率分别为82.35%、76.93%，差异没有统计学意义（P>0.05）。客观体征有效率分别为85.29%、57.69%，差异显著（P<0.05）。结论 强脉冲光联合吡美莫司乳膏治疗激素依赖性皮炎有较好的临床疗效。

关键词：强脉冲光；激素依赖性皮炎；吡美莫司

中图分类号：R758.22文献标志码：A文章编号：2096-1413(2017)05-0006-02

Clinical observation of intense pulsed light and pimecrolimus cream in the

treatment of hormone-dependent facial dermatitis
LIU Ying, WU Ning
(Xianyang Central Hospital, Xianyang 712000, China)

ABSTRACT: Objective To evaluate the therapeutic effect of intense pulsed light and pimecrolimus cream in the treatment of hormone -dependent facial dermatitis. Methods Sixty patients with hormone -dependent facial dermatitis in the department of dermatology in our hospital were chosen and randomly divided into treatment group and control group. The treatment group (34 patients) was treated with intense pulsed light and pimecrolimus cream. The intense pulsed light was given with an interval of 4 weeks for 5 months, and pimecrolimus cream was externally used 1 time per night. The control group (26 patients) was only treated with pimecrolimus cream 1 time per night for 5 months. The curative effects were evaluated in the two groups before and after treatment respectively. Results After therapy, the objective symptom and the subjective symptom scores in the two groups were statistically significant (P<0.05). The efficacy rates of objective symptom in the treatment group and the control group were 82.35% and 76.93% respectively, the differences were not statistically significant (P>0.05). The efficacy rate of subjective symptom in the treatment group and the control group were 85.29% and 57.69% respectively, the differences were statistically significant (P <0.05). Conclusion Intense pulsed light and pimecrolimus cream has significant effect in the treatment of hormone-dependent facial dermatitis.
KEYWORDS: intense pulsed light; hormone-dependent dermatitis; pimecrolimus

参考文献：
[1] 陈用军,丁东坤,叶轮,等.面部糖皮质激素依赖性皮炎患者心理状况、生活质量调查及心理护理临床研究[J].中国美容医学,2013,22(8):840-843.
[2] 顾恒援糖皮质激素依赖性皮炎的诊断与治疗[J].中华皮肤科杂志,2007,40(1):5-6.
[3] 胡志帮,张莉,张昆梅,等.强脉冲光治疗激素依赖性皮炎疗效观察 [J].中国麻风皮肤病杂志,2015,31(5):309-310.
[4] SHIBATA M,KATSUYAMA M,ONODERA T,et al.Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimu- lated with propionibacterium acnes or proinflammatory cytokines [J].J Invest Dermatol,2009,129(2):375-382.
[5] 吴景良,徐西红,张理涛.面部激素依赖性皮炎皮损中T淋巴细胞亚群的分析[J].中国皮肤性病学杂志,2013,27(7):665-666.

[6] 起珏.外用糖皮质激素对皮肤屏障的结构和功能的影响[J].中国美容医学,2011,20(1):171-173.
[7] 周东,白用晟,梁超.强脉冲光子嫩肤术治疗面部激素依赖性皮炎的疗效观察[J].中国激光医学杂志,2010,19(3):177-179.
[8] 王国江,董达科,张海清,等.强脉冲光对巴马香猪糖皮质激素诱导的皮炎模型皮肤组织病理的影响[J].中华皮肤科杂志,2011,44(11):797-799.
[9] HERN NDEZP REZ E,IBIETT EV.Cross and microscopic finding in patients submitted to nonablative full-face resurfacing using intense pulsed light: a preliminary study[J].Dermatol Surg,2002,28(8):651.
[10] NEGISHI K,WAKAMATSU S,KUSHIKATA N,et al.full-face photo rejuvenation of photodamaged skin by intense pulsed light with integrat- ed contact cooling initial experiences in Asian patients [J].Lasers Surg Med,2003,30(4):298.
[11] PRIETO VG,ZHANG PS,SADICK NS.Evaluation of pulsed light and radiofrequency combined for the treatment of acne vulgaris with histologic analysis of facial skin biopsies[J].Cosmet Laser Ther,2009,7(2):63.
[12] 田蓉,乔丽.昆明山海棠联合1%吡美莫司治疗面部激素依赖性皮炎疗效观察[J].武警医学,2013,24(9):777-779.