美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床疗效对比

马维雄

（陕西省榆林市第一医院，陕西 榆林，718000）

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摘要：

目的 探究美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床疗效。方法 随机选取2014年1月至2015年12月在我院就诊的溃疡性结肠炎患者130例，随机分为观察组与对照组，每组65例。对照组采用柳氮磺吡啶治疗，观察组则采用美沙拉嗪治疗，观察两组患者的临床疗效。结果 对照组患者治疗总有效率为83.08%，观察组治疗总有效率为96.92%；对照组不良反应发生率为12.31%，观察组不良反应发生率为1.54%，两组比较差异均有统计学意义（P<0.05）；观察组治疗后组织学积分 明显低于对照组，差异具有统计学意义（P<0.05）。结论 美沙拉嗪与柳氮磺吡啶均可用于治疗溃疡性结肠炎，但美沙拉嗪的临床疗效更明显，安全性更高，有进一步临床推广的价值。

 

关键词：美沙拉嗪；柳氮磺吡啶；溃疡性结肠炎

中图分类号：R574.62文献标志码：A文章编号：2096-1413(2017)04-0035-02

The effect comparison of mesalazine and sulfasalazine in the treatment of ulcerative colitis
MA Wei-xiong
(the First Hospital of Yulin, Yulin 718000, China)

ABSTRACT: Objective To explore the curative effect of mesalazine and sulfasalazine in the treatment of ulcerative colitis. Methods From January 2014 to December 2015, 130 cases of ulcer colitis patients were randomly divided into observation group and control group, with 65 cases in each group. The control group was treated with sulfasalazine treatment, the observation group was treated with mesalazine, the curative effect of two groups was compared. Results In the control group, the total effective rate was 83.08%, while the observation group was 96.92%; in the control group, the incidence rate of adverse reaction was 12.31%, while the observation group was 1.54%, the differences were statistically significant (P<
0.05). The histological score of the observation group was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion Mesalazine and sulfasalazine can be used in the treatment of ulcerative colitis, but mesalazine is more safe and effective, which is worthy of clinical application.
KEYWORDS: mesalazine; sulfasalazine; ulcerative colitis

参考文献：
[1] 黄明,吴雄健.比较美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的效果观察[J].医学信息,2013,26(24):515-516.
[2] 柳汝明,吴斌,赵雨晋,等.美沙拉嗪与柳氮磺吡啶比较治疗溃疡性结肠炎疗效与安全性的系统评价[J].中国循证医学杂志,2011,11(2):181-186.
[3] 沈学明.美沙拉嗪及SASP 治疗溃疡性结肠炎的临床疗效比较[J]. 中国现代药物应用,2012,6(12):3-4.
[4] 张丽仙.美沙拉嗪灌肠液治疗溃疡性结肠炎30 例临床疗效观察 [J].临床合理用药杂志,2011,4(35):40-41.
[5] 温育鹏,胡亚丽.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效 对比研究[J].当代医学,2011,17(4):138-139.
[6] 曾照秋.美沙拉嗪及柳氮磺砒啶在治疗溃疡性结肠炎中的疗效对比[J].中国现代药物应用,2013,7(10):99-100.
[7] 魏晓广,高春献,古劼劼,等.美沙拉嗪口服联合灌肠治疗溃疡性结肠炎120例疗效观察[J].医药论坛杂志,2011,32(10):87-88.
[8] 甄春山,袁俏娴.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效对比研究[J].中外医学研究,2013,26(32):40-41.
[9] 李恩峰,李颖华,张亚丽.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效对比研究[J].医学信息旬刊,2013,26(8):307-308.
[10] 黄宏政.美沙拉嗪治疗溃疡性结肠炎疗效观察[J].中国民族民间医药,2013,22(8):79.