厄贝沙坦氢氯噻嗪片联合螺内酯治疗老年心力衰竭临床疗效观察
徐凡叶，刘涛
（第四军医大学第三附属医院老年病科，陕西 西安，710032）
浏览次数：539次 下载次数：396次
摘要：
目的 对厄贝沙坦氢氯噻嗪片联合螺内酯在老年心力衰竭治疗中的临床疗效和安全性进行探讨。方法 选取2001年1月至2015年3月我院收治的老年心力衰竭患者100例作为研究对象，随机分为观察组和对照组，各50例。对照组患者给予常规治疗方法进行治疗，观察组患者在采用常规治疗的基础上给予厄贝沙坦氢氯噻嗪片联合螺内酯，比较两组患者的治疗效果。结果 观察组治疗总有效率为92.00%，显著高于对照组的76.00%（P<0.05）；观察组及对照组治疗后6min步行距离和BNP较治疗前均有显著改善（P<0.05），且观察组改善程度优于对照组（P<0.05）。结论 厄贝沙坦氢氯噻嗪片联合螺内酯可显著改善老年心力衰竭患者的心功能，具有较高的临床应用价值。
关键词：厄贝沙坦氢氯噻嗪片；螺内酯；老年心力衰竭
中图分类号：R541.6文献标志码：A文章编号：2096-1413(2017)04-00员员-02
栽he effect analysis of irbesartan and hydrochlorothiazide tablets combining
spirolactone on elderly heart failure
XU Fan-ye, LIU Tao
(Department of Gerontology, the Third Afiiliated Hospital of the Fourth Military Medical University, Xi'an 710032, China)
ABSTRACT: Objective To investigate the effect of irbesartan and hydrochlorothiazide tablets combining spirolactone on elderly heart failure. Methods One hundred cases of elderly heart failure patients were selected from January 2001 to March 2015 and randomly divided into control group (fifty cases) using usual cures and observation group (fifty cases) using usual cures, irbesartan and hydrochlorothiazide tablets and spirolactone, the therapeutic effect was compared between the two groups. Results The therapeutic effect in the observation group was significantly higher than that in control group (92.00% vs. 76.00%, P<0.05). After the treatment, the walking distance within 6 min and BNP were significantly improved in both groups and the improvement degree in the observation group was significantly better than that in the control group (P<0.05). Conclusion There is a great application value of irbesartan and hydrochlorothiazide tablets and spirolactone in elderly heart failure.
KEYWORDS: irbesartan and hydrochlorothiazide tablets; spirolactone; elderly heart failure
参考文献：
[1] 陶博,曹丰,赵志敬,等.重组人脑钠尿肽治疗急性失代偿心力衰竭中不同水钠潴留程度患者的疗效[J].心脏杂志,2010,22(5):719-723.
[2] 唐思文,徐登峰,王玲玲,等.芪苈强心胶囊多目标优化组合物对实验性心衰大鼠心功能的保护作用[J].中药新药与临床药理,2011,22(5):532-535.
[3] 刘建,马金萍,黄娇红,等.指南对老年慢性充血性心力衰竭住院患者药物治疗的影响[J].中国危重病急救医学,2010,22(10):606-609.
[4] 王红,张春霞,阎丽,等.老年慢性心率衰竭N 末端钠尿肽前体和心率变异性与心功能的相关性[J].中华老年心脑血管病杂志,2013,15(11):1146-1148.
[5] 钱方毅.重视心力衰竭发病机制中的神经内分泌细胞因子系统的研究[J].中国循环杂志,2001,16(4):243-245.
[6] 夏翼.养心活血汤治疗气虚血瘀型慢性充血性心力衰竭的临床疗效观察[D].南京:南京中医药大学,2009.
[7] 孙勤梅,郑龑.扩张型心肌病的诊断与治疗体会[J].中国医药指南,2012,10(23):486-487.
[8] 黄健.中药穴位敷贴辅助治疗慢性收缩性心力衰竭的疗效观察[D]. 济南:山东中医药大学,2012.
[9] 于昊.1258例慢性心力衰竭住院病例回顾性调查分析[D].长春:吉 林大学,2011.