MicroRNAs在心肌梗死后心肌纤维化中的作用

陈宏丹，董少红

（1.暨南大学第二临床医学院，广东深圳，518020；2 深圳市人民医院心内科，广东深圳，518020）

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摘要：

心肌梗死是一类严重危害人类健康和生命安全的重要疾病，心肌梗死后心脏重构导致的心力衰竭是患者发生不良预后及死亡的主要原因。心肌纤维化是心肌梗死后心脏重构最重要的病理过程之一，其发生机制可能涉及到细胞凋亡及细胞信号调节等，MicroRNAs（miRNAs）可通过调控多种与心肌纤维相关的信号通路和抑制多种细胞外基质蛋白的表达参与心肌纤维化过程，本文对与心肌梗死后心肌纤维化相关的几种主要miRNAs 的表达、调控及其心脏修复的作用作一综述。

关键词：miRNAs；心肌梗死；心肌纤维化

中图分类号：R542.22文献标志码：A文章编号：2096-1413(2017)03-0194-02

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