丙戊酸钠联合拉莫三嗪应用于各型癫痫病治疗中的临床效果
辛建勋，任麦存
（1.宝鸡市眉县人民医院神经内科，陕西 宝鸡，722300；2.宝鸡市眉县中医医院神经内科，陕西 宝鸡，722300）
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摘要：
目的 探讨丙戊酸钠联合拉莫三嗪治疗各型癫痫病的疗效及安全性。方法 选取我院2013年4月至2016年1月诊治的各型癫痫病患者84例为研究对象，按照随机抽签方法分组，治疗组（n=42）应用丙戊酸钠联合拉莫三嗪治疗，对照组（n=42）单纯采取丙戊酸钠治疗，比较两组患者治疗总有效率和不良反应发生率。结果 治疗组的治疗总有效率是97.62%，不良反应发生率是7.14%；对照组的治疗总有效率是80.95%，不良反应发生率是14.29%；两组患者治疗总有效率与不良反应发生率比较差异有统计学意义（P<0.05）。结论 丙戊酸钠联合拉莫三嗪治疗各型癫痫病的疗效确切，且患者用药安全性较高，有推广意义。
关键词：丙戊酸钠；拉莫三嗪；各型癫痫病
中图分类号：R742.1文献标志码：A文章编号：2096-1413(2017)03-0048-02
Observation of clinical effect of sodium valproate combined with lamotrigine in
treatment of different types of epilepsy
XIN Jian-xun 1, REN Mai-cun 2
(1. Department of Neurology, People's Hospital of Mei County, Baoji 722300; 2. Department of Neurology,
Chinese Medicine Hospital of Mei County, Baoji 722300, China)
ABSTRACT: Objective To discuss the clinical effect and safty of sodium valproate combined with lamotrigine in treatment of different types of epilepsy. Methods From April 2013 to January 2016, eighty-four cases with all types of epilepsy in our hospital were devided into two groups randomly, the treatment group (n=42) received sodium valproate joint lamotrigine, the control group (n=42) took valproic acid treatment, the two groups of patients overall treatment effectiveness and incidence of adverse reactions were compared. Results The total effective rate of the treatment group was 97.62%, and the adverse reaction rate was 7.14%, while the control group was 80.95% and 14.29% respectively, the differences were statistically significant (P<0.05). Conclusion Combined effect of sodium valproate and lamotrigine in the treatment of various types of epilepsy is remarkable and safety, which is worthy of promotion.
KEYWORDS: sodium valproate; lamotrigine; various types of epilepsy
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