ST段抬高型急性心肌梗死患者的BNP浓度与冠脉病变程度、PCI治疗预后的相关性研究

任浩进，王丽岳，黄莉芳

（武汉市普仁医院心内科，湖北 武汉，430080）

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摘要：

目的 探讨ST段抬高型急性心肌梗死（STEMI）患者的血浆B型钠尿肽（BNP）浓度与冠脉病变程度以及经皮冠状动脉介入（PCI）治疗预后的相关性。方法 根据STEMI中的BNP浓度依次从高到低将160例STEMI患者分为四组，分别为 ≦ P25（106 ng/L）组、P26~P50（106.1~341 ng/L）组、P51~P75（341.1~1 190 ng/L）组、>P75（1 190 ng/L）组，并对四组患者的冠脉造影以及PCI治疗预后的情况进行对比与分析。结果 四组患者的冠脉病变的多支病变发生率均高于单支病变（P<0.05）；血浆BNP水平与冠脉病变程度之间呈正相关（P<0.05）。四组患者的Gensini评分有差异，且>P75 组Gensini 评分显著高于 P51~P75 组、P26~P50 组、 ≦ P25 组（P<0.05）；血浆BNP水平与Gensini评分呈正相关（P<0.05）。四组患者的心血管疾病的发生率有差异，且>P75 组显著高于其他三组（P<0.05）；血浆BNP水平与心血管事件发生率呈正相关（P<0.05）。结论 STEMI患者的BNP水平越高，冠脉病变程度加重且心血管发生率增高，BNP可以作为诊断STEMI 病情的指标。

关键词：BNP 浓度；冠脉病变程度；PCI治疗预后；ST段抬高型急性心肌梗死

中图分类号：R542.2+2文献标志码：A文章编号：2096-1413(2017)03-0038-02

The correlation research of BNP concentration to the degree of coronary artery

lesion and the prognosis after PCI in patients with
ST-elevation acute myocardial infarction

REN Hao-jin, WANG Li-yue, HUANG Li-fang
（Department of Cardiology, Wuhan PuRen Hospital, Wuhan 430080, China）

ABSTRACT: Objective To investigate the correlation of plasma b-type natriuretic peptide (BNP) concentration to the degree of the coronary artery lesions and the prognosis after percutaneous coronary intervention (PCI) therapy in patients with ST-elevation acute myocardial infarction (STEMI). Methods One hundred and sixty cases of STEMI patients were divided into four groups according to BNP concentrations , they were ≦ P25 (106 ng/L) group, P26-P50 (106.1-341 ng/L) group, P51-P75 (341.1-1 190 ng/L)group, and >P75 (1 190 ng/L). The coronary angiography and PCI treatment prognosis among the four groups were compared and analyzed. Results The patients among the four groups, the incidence rate of multi-vessel disease was higher than the single-vessel disease (P<0.05); and there was a positive correlation between the plasma BNP level and the degree of coronary artery lesion (P<0.05). There were differences among the four groups in Gensini scores, and the Gensini score of >P75 group was higher than that of the other three groups (P<0.05); there was a positive correlation between the plasma BNP level and Gensini score (P<0.05). Significant differences were found among the four groups in incidence of ardiovascular diseases (P<0.05); and the correlation between the plasma BNP level and occurrence rate of cardiovascular diseases was positive (P<0.05). Conclusion For patients with STEMI, the higher the BNP
level are, the more aggravating the coronary artery disease extension are, and the higher rate of occurrence of the cardiovascular disease are. So BNP could be used as a diagnostic index of STEMI pathogenetic condition.
KEYWORDS: BNP concentration; coronary artery lesion severity; PCI treatment prognosis; ST-elevation acute myocardial infarction

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