熊去氧胆酸联合辛伐他汀治疗脂肪肝合并高脂血症的随机对照研究

张强

（浙江省玉环县人民医院，浙江 台州，317600）

浏览次数：181次 下载次数：290次

摘要：

目的 探究熊去氧胆酸联合辛伐他汀治疗脂肪肝合并高脂血症的临床疗效。方法 选择我院100例高脂血症合并脂肪肝患者，根据治疗方法的不同分为两组，各50例。观察组行熊去氧胆酸联合辛伐他汀治疗，对照组行熊去氧胆酸单纯治疗。对治疗前、后两组患者的血脂和肝功能指标进行检测，比较两组治疗效果。结果 观察组血脂和肝功能指标治疗后均明显改善（P<0.05），治疗有效率明显高于对照组（P<0.05）。结论 对脂肪肝合并高脂血症患者采用熊去氧胆酸联合辛伐他汀治疗效果显著。

关键词：脂肪肝；高脂血症；熊去氧胆酸；辛伐他汀

中图分类号：R589.2文献标志码：A文章编号：2096-1413(2017)03-0028-02

The randomized controlled study of ursodeoxycholic acid combined with simvastatin

in treatment of fatty liver with hyperlipidemia
ZHANG Qiang
(Yuhuan County People's Hospital, Taizhou 317600, China)

ABSTRACT: Objective To explore the clinical effect of ursodeoxycholic acid combined with simvastatin in treatment of fatty liver with hyperlipidemia. Methods One hundred patients of fatty liver with hyperlipidemia in our hospital were selected and divided into two groups according to different treatment methods, with 50 cases in each group. The observation group accepted ursodeoxycholic acid (UDCA) combined with simvastatin, and the control group accepted UDCA alone. The blood lipid and liver function indicators before and after treatment were tested in the two groups to compare the treatment efficiency. Results The blood lipid and liver function indicators in the observation group were significantly improved after treatment, the treatment efficiency was significantly higher than that in the contron group (P<0.05). Conclusion For patients of fatty liver with hyperlipidemia, ursodeoxycholic acid combined with simvastatin had a remarkable effect.
KEYWORDS: fatty liver; hyperlipidemia; ursodeoxycholic acid; simvastatin

参考文献：

[1] 展玉涛.非酒精性脂肪性肝炎药物治疗的临床研究进展[J].临床荟萃,2006,21(4):290-292.
[2] 茅益民,邱德凯,曾民德.熊去氧胆酸治疗慢性肝病的多中心临床研究[J].肝脏,1999,4(4):221-223.
[3] 郭江鸿.B型超声对中老年脂肪肝的诊断及临床意义[J].中国医药导刊,2009,11(2):193-194.
[4] 陈良.熊去氧胆酸联合辛伐他汀治疗非酒精性脂肪性肝病合并高脂血症的临床疗效观察[J].福建医药杂志,2015,37(5):85-87.
[5] 阿艳春.使用熊去氧胆酸联合辛伐他汀对脂肪肝合并高脂血症患者进行治疗的效果观察[J].当代医药论丛,2016,14(10):96-97.
[6] 李韦,王枫,吕宗舜,等.熊去氧胆酸治疗非酒精性脂肪性肝病的系统评价[J].世界华人消化杂志,2013,21(23):2335-2343.