复合凝乳酶治疗儿童功能性消化不良的临床观察

李刚

（西北妇女儿童医院消化科，陕西 西安，710061）

浏览次数：151次 下载次数：440次

摘要：

目的 观察分析复合凝乳酶治疗儿童功能性消化不良的临床效果。方法 将我院收治的97例功能性消化不良患儿随机分为对照组（n=48）和研究组（n=49）。对照组采用西沙比利治疗，研究组采用复合凝乳酶胶囊治疗，两组患儿连续给药4周， 每周随访1次，观察两组患儿治疗前后上腹不适、上腹痛、腹胀、恶心、呕吐、早饱、嗳气、食欲下降等临床症状的变化情况并进行评分。结果治疗前，两组患儿的症状评分无显著差异（P>0.05）；随用药时间的加长，两组患儿的临床症状积分逐渐下降，用药4周后症状积分与治疗前相比显著降低（P<0.05），研究组患儿的症状积分明显低于对照组（P>0.05）。用药后，两组患儿的总有效率均逐步升高，用药4周后，研究组的总有效率为81.63%，显著高于对照组的75.00%（P<0.05），差异有统计学 意义（P<0.05）。用药过程中，两组患儿均未出现严重不良反应。结论 采用复合凝乳酶治疗儿童功能性消化不良，有较好的临床疗效，能有效改善患儿的不良症状，且副作用少。

关键词：功能性消化不良；复合凝乳酶；症状积分

中图分类号：R725.7文献标志码：A文章编号：2096-1413(2017)02-0075-02

Clinical observation of compound rennet on children's functional dyspepsia
LI Gang
(Department of Gastroenterology, the Northwest Women and Children Hospital, Xi'an 710000, China)

ABSTRACT: Objective To observe and analyze the clinical effect of compound rennet in the treatment of children's functional dyspepsia. Methods Ninety-seven cases of patients with children's functional dyspepsia were randomly divided into control group (n=48) and research group (n=49). The control group was taken cisapride, while the research group was taken compound rennet capsule, the two groups had successive administration for four weeks. All the patients were followed up for 1 times a week. The epigastric discomfort, upper abdominal pain, abdominal distention, nausea, emesis, early satiety, belching, loss of appetite and other clinical symptoms of the two groups before treatment and after treatment were observed and scored. Results Before treatment, the symptom scores of the two groups had no significant difference (P>0.05). Along with the medication duration, the control group and the research group's clinical symptoms integral gradually declined, the symptoms integral after 4 weeks was significantly lower than that before treatment (P<0.05), and the symptoms integral of the research group were obviously less than that of the control group (P<0.05). After medication, the total effective rate of the two groups were gradually rose; after 4 weeks, the total effective rate of the research group was 81.63%, which was significantly higher than 75.00% of the control group, the difference was statistically significant (P<0.05). During drug using period, two groups had no serious adverse drug reactions occurred. Conclusion Compound rennet treatment on children's functional dyspepsia has good therapeutic effect. It can effectively improve the patient's symptoms, and has lower non-toxic side effects.
KEYWORDS: functional dyspepsia; compound rennet; symptoms integral

参考文献：
[1] 徐嘉莉.儿童功能性消化不良的再认识附56 例临床分析[J].大家健康,2013,7(3):2-3.
[2] 刘满娇,刘敏,孙翠薇.儿童功能性消化不良的胃动力学与复合凝乳酶胶囊疗效的研究[J].中外医学研究,2014,11(31):23-24.
[3] 中华医学会儿科学分会消化学组《,中华儿科杂志》编辑委员会援中国儿童功能性消化不良诊断和治疗共识[J].中华儿科杂志,2012,50(6):423-424.
[4] 蒋芝山.奥美拉唑联合马来酸曲美布汀治疗功能性消化不良55例[J].陕西医学杂志,2011,40(6):765.
[5] 张宏伟,张新义,赵民.功能性消化不良患者空腹胃窦运动测定及其胃窦面积与胃液量的关系[J].中国药物与临床,2011,11(12):1442-1443.
[6] 李建.功能性消化不良临床治疗的研究进展[J].中国老年学杂志,2011,31(13):2599-2601.
[7] 周涯.复合凝乳酶治疗胃肠功能紊乱所致儿童厌食、食欲不振、消化不良等的临床疗效观察[J].当代医学,2012,18(4):148-149.