缩宫素联合米索前列醇治疗子宫收缩乏力引起的产后出血的疗效观察

高显舜 ，连荣丽，李芬

1. 西安交通大学第一附属医院妇产科，陕西 西安 710061；2.陕西省安康市妇幼保健院妇产科，陕西 安康 725000）

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摘要：

目的 探讨缩宫素联合米索前列醇治疗子宫收缩乏力引起的产后出血的疗效。方法 选择2012年1月至2013年12月 200例产后宫缩乏力性出血的患者，分为观察组102例和对照组98例。两组患者均在胎儿娩出时给予20 IU 缩宫素加入 500 mL 5%葡萄糖溶液中静滴，观察组患者在此基础上加用400 μg 米索前列醇直肠给药，对照组患者加用20 IU 缩宫素子 宫肌层注射，观察两组患者子宫收缩，出血、Hb 和Hct 水平以及不良反应。结果 观察组子宫收缩能力良好率为93.1%，高 于对照组的82.7%（P<0.05）；观察组患者总有效率为95.1%，高于对照组的84.2%（P<0.05）；观察组产后2、24 h 出血量少于对照组（P<0.05）；观察组的Hb、Hct 水平均高于对照组（P<0.05）；两组患者的不良反应发生率比较差异不显著（P >0.05）。结论 缩宫素联合米索前列醇治疗子宫收缩乏力引起的产后出血疗效好，安全性高，有较高的临床使用价值。 

关键词：缩宫素；米索前列醇；子宫收缩乏力；产后出血

中图分类号：R714.461文献标志码：A文章编号：2096-1413(2017)01-0108-02

Effect of oxytocin combined with misoprostol in the treatment of postpartum hemorrhage caused by

uterine contraction fatigue
GAO Xian-shun, LIAN Rong-li, LI Fen
(1. Obstetrics and Gynecolog Department, the First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061; 2. Obstetrics and Gynecolog Department, Ankang Municipality Maternity and Child Health Care, Ankang 725000, China)

ABSTRACT: Objective To investigate the effect of oxytocin combined with misoprostol in the treatment of postpartum hemorrhage caused by uterine contraction fatigue. Methods From January 2012 to December 2013, 200 cases of uterine contraction fatigue bleeding were divided into observation group (102 cases) and control group (98 cases), two groups of patients were given 20 IU oxytocin complicated with 500 mL of 5% glucose solution in the delivery of the fetus. The observation group was treated with 400 μg misoprostol rectal administration and the control group was given 20 IU oxytocin by myometrium injection. The two groups of patients with uterine contraction, bleeding, Hb and Hct level, and adverse reactions were observed. Results The good rate of uterine contraction ability was higher than that in control group (93.1% vs. 82.7%) (P<0.05); the total effective rate in the observation group was higher than that in the control group (95.1% vs. 84.2%) (P<0.05); the amount of postpartum hemorrhage of observation group was less than that of the control group (P<0.05); the levels of Hb and Hct in the observation group were higher than those in the control group (P<0.05); the adverse reactions of the two groups of patients occurrence had no significant difference (P>0.05). Conclusion Oxytocin combined with misoprostol in the treatment of postpartum hemorrhage caused by uterine contraction fatigue is safe and effective, which is suitable for clinical application.
KEYWORDS: oxytocin; misoprostol; uterine contraction fatigue; postpartum hemorrhage

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