降钙素原及 C 反应蛋白对重度脓毒血症预后的评估价值

温建芳，吴慧锋 * ，贺建平，王鹏森

铜川市人民医院急诊科，陕西 铜川，727000

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摘要：

目的 探讨降钙素原（PCT）和 C 反应蛋白（CRP）对重度脓毒血症患者预后的评估价值。方法 选取我院收治的脓毒血症100例作为疾病组，另选取健康志愿者 100例作为健康组。疾病组患者给予常规支持治疗，两组均采用酶联免疫法检测血清PCT、CRP水平。比较健康组与疾病组、疾病组不同病情严重程度、疾病组治疗后不同预后情况患者的血清 PCT、CRP 水平。结果 疾病组 PCT 和 CRP 血清因子水平高于健康组（P＜0.05）；疾病组患者中，中、重度患者血清 PCT 和 CRP 水平明显高于轻度患者，重度患者血清 PCT 和 CRP 水平高于中度患者（P＜0.05）；疾病组患者中，预后不良患者血清 PCT 和 CRP 水平高于预后良好患者（P＜0.05）。结论 PCT 及 CRP水平在重度脓毒血症患者血清中均异常升高，其对病情判断和预后评估均有指导意义。

关键词： 降钙素原；C 反应蛋白；重度脓毒血症

中图分类号：R459.7 文献标志码：A文章编号： 2096-1413(2018)08-0026-02

Evaluation value of procalcitonin and C-reactive protein in the prognosis of severe sepsis

WEN Jian-fang,W U Hui-feng * ,HE Jian-ping,W ANG Peng-sen
(EmergencyDepartment,thePeople`sHospitalofTongchuan,Tongchuan 727000,China)

ABSTRACT: Objective To investigate the evaluation value of procalciton in (PCT) and C-reactive protein (CRP) in the prognosis ofsevere sepsis. Methods One hundred severe sepsis patients admitted in our hospital were selected as the disease group,and another 100 healthy volunteers were enrolled as the healthy group.Patients in the disease group were treated with routine supportive treatment.The serum PCT and CRP levels of the two groups were detected by enzyme linked immunosorbent assay.The serum PCT and CRP levels between healthy group and disease group,different disease severity and different prognosis  after treatment in the disease group were compared. Results The serum PCT and CRP levels of the disease group were higher than those of the healthy group (P<0.05).In the disease group, the levels of serum PCT and CRP in moderate and severe patients were significantly higher than those in mild patients,and the levels of serum PCT and CRP in severe patients were significantly higherthan those in moderate patients (P<0.05).In the disease group the levels of serum PCT and CRP in patients with poor prognosis were higher than those in patients with good prognosis (P<0.05). Conclusion The serum levels of PCT and CRP increase significantly in severe sepsis patients,which have ideal guiding significance for disease judgment and prognosis evaluation.                                                                    KEYWORDS: procalcitonin; C-reactiveprote in; severesepsis

 

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