冻干重组人脑利钠肽对急性心肌梗死 PCI术后 合并急性心力衰竭的疗效

邢玉洁，赵娜，马美娟，唐治国，崔倩卫，王军奎

陕西省人民医院心内一科,陕西 西安，710068

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摘要：

目的 探讨冻干重组人脑利钠肽对急性心肌梗死 PCI术后合并急性心力衰竭的临床疗效。方法 将 60例急性心肌梗死PCI术后合并急性心力衰竭的患者随机分为对照组和试验组，各 30例。对照组给予常规药物治疗，试验组在对照组基础上给予冻干重组人脑利钠肽治疗。观察比较两组的治疗效果、不良反应情况、cTnI、CK-MB、BNP 水平、LVEF 及 LVFS。结果 试验组总有效率显著高于对照组（P＜0.05）。治疗后，两组的 cTnI、CK-MB、BNP 水平均显著低于治疗前，且试验组显著低于对照组（P＜0.05）；两组的 LVEF 和 LVFS均较治疗前显著升高，且试验组高于对照组（P＜0.05）。两组不良反应发生率无明显差异（P>0.05）。结论 冻干重组人脑利钠肽可以显著提高急性心肌梗死 PCI术后合并急性心力衰竭患者的治疗效果，减少心肌损害，提高患者的心功能，且不良反应少。

关键词：冻干重组人脑利钠肽；急性心肌梗死；急性心力衰竭

中图分类号：R541.6；R542.22文献标志码：A文章编号：2096-1413(2018)07-0007-03

Therapeutic effect of lyophilized recombinant human brain natriuretic peptide
on acute myocardial infarction with acute heart failure after PCI


XING Yu-jie,ZHAO Na,MA Mei-juan,TANG Zhi-guo,CUI Qian-wei,WANG Jun-kui *
(No.1 Cardiology Department, Shaanxi Provincial People`s Hospital, Xi`an 710068,China)



ABSTRACT: Objective To investigate the the rapeutic effect of lyophilized recombinant human brain natriuretic peptide on acute myocardial infarction with acute heart failureafter PCI. Methods A total of 60 patients of acute myocardial infarction with acute heartfailure afterPCIwere randomlydivided into control group and experimental group,with 30 cases in each group.The control group receivedc onventional medic inetherapy,and the experimental group was given lyophilize drecombinant human brain natriuretic peptide on the basis of the control group.The treatment effects,adversere actions,the levels of cTnI,CK-MB and BNP,LVEF and LVFS were observed and compared between the two groups. Results The total effective rate in the experimental group was significantly higher than thatin the control group (P<0.05).After treatment,the levels of cTnI,CK-MB and BNP of both groups were significantly lower than those  before  treatment, and those  in the experimental group were significantly lower than the control group (P<0.05); the LVEF and LVFS in both groups were significantly higher than those before treatment,and those in the experimental group were higher than the control  group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion  Lyophilized recombinant huma brain natriuretic peptide can significantly improve the the rapeutic effect of acute myocardial infarction patients with acute heart failure after PCI, reduce myocardial damage,improve cardiac function, and  has fewer adverse reaction.
KEYWORDS: lyophilized recombinant human brain natriuretic peptide;acute myocardialinfarction; acute heartfailure

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