匹多莫德防治小儿抗生素相关性腹泻的临床疗效及其对患儿血液炎性因子的影响

王会玲1，温慧1 ，杜薇2*

（1.西安长安医院儿科，陕西 西安，710016；2.渭南市第二医院外一科，陕西 渭南，714000）

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摘要：

目的 探讨匹多莫德防治小儿抗生素相关性腹泻（AAD）的临床疗效及其对患儿血液炎性因子水平的影响。方法 以我 院收治的92例AAD患儿作为研究对象，随机分为观察组与对照组，各46 例。所有患儿入院后均继续原发病的抗感染、益生菌补充肠道菌群、止泻及补充电解质等常规治疗。观察组在上述基础上给予口服匹多莫德治疗。检测患儿血清白介素指标及 其他相关炎性因子水平，同时观察两组患儿胃肠道症状缓解情况。结果 观察组治疗总有效率均明显高于对照组（P<0.05）；观察组患儿恶心、呕吐、腹泻、发热缓解时间和总治愈时间明显短于对照组（P<0.05）。治疗后，两组患儿血清白介素指标及其 他相关炎性因子水平均明显改善，且观察组患儿的上述指标水平明显优于对照组（P<0.05）；治疗过程中，两组患儿均未出现 明显不良反应。结论 匹多莫德防治小儿抗生素相关性腹泻具有较好的临床疗效，同时还能有效改善患儿炎性因子水平，值 得进行深入探讨。

关键词：抗生素相关性腹泻(AAD)；匹多莫德；血液炎性因子

中图分类号：R725.6文献标志码：A文章编号：2096-1413(2018)06-0092-03

Clinical efficacy of pidotimod in the prevention and treatment of children with antibiotic associated diarrhea and its influences on blood inflammatory factors
WANG Hui-ling1, WEN Hui 1, DU Wei 2 *
(1. Pediatrics Department, Chang``an Hospital, Xi``an 710016; 2. the First Surgery Department, the Second Hospital of Weinan, Weinan 714000, China)

ABSTRACT: Objective To investigate the clinical efficacy of pidotimod in children with antibiotic associated diarrhea (AAD) and its influences on blood inflammatory factors. Methods A total of 92 cases of AAD children received in our hospital were selected as the study objects, and randomly divided into observation group and control group, with 46 cases in each group. All the children were treated with routine treatment such as anti -infection, probiotics supplement intestinal flora, antidiarrheal and electrolyte supplement. The observation group received oral pidotimod on the basis of the above -mentioned. The levels of serum interleukin and other related inflammatory factors were measured, and the remission of gastrointestinal symptoms in the two groups was observed at the same time. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The nausea, vomiting, diarrhea, fever remission time and total cure time in the observation group were significantly shorter than those in the control group (P <0.05). After treatment, the levels of serum interleukin and other related inflammatory factors in the two groups significantly improved, and the levels of the indexes above of the observation group were significantly better than the control group (P<0.05). There was no obvious adverse reactions in the two groups during the treatment. Conclusion Pidotimod in the treatment of children with antibiotic associated diarrhea has good clinical efficacy, which can effectively improve the level of inflammatory factors in children, it is worthy of further study.
KEYWORDS: antibiotic-associated diarrhea (AAD); pidotimod; blood inflammatory factors

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