奥拉西坦联合高压氧治疗脑外伤综合征的疗效分析

施丽琴1，杨文进2 ，方琴1，曹利敏1

（上海市浦东新区人民医院：1.高压氧科；2.神经外科，上海，201299）

浏览次数：110次 下载次数：379次

摘要：

目的 观察奥拉西坦联合高压氧治疗脑外伤综合征的疗效。方法 选取我院收治的脑外伤综合征患者96 例，随机将其 分为治疗组及对照组，各48 例。两组患者组均给予常规治疗，对照组在常规治疗基础上予以奥拉西坦药物治疗；治疗组在对 照组基础上给予高压氧治疗。比较两组患者的临床疗效和FIM 评分。结果 治疗组患者的治疗总有效率高于对照组（P< 0.05）。治疗后，两组患者的FIM 评分均升高，且治疗组优于对照组（P<0.05）。结论 奥拉西坦联合高压氧治疗可明显改善脑组 织缺氧，促进脑细胞功能恢复，有效改善患者临床症状，提高患者的日常独立生活能力，值得临床推广、应用。

关键词：奥拉西坦；高压氧；脑外伤综合征

中图分类号：R651.15 文献标志码：A文章编号：2096-1413(2018)04-0033-02

Efficacy analysis of hyperbaric oxygen combined oxiracetam on post-traumatic brain syndrome
SHI Li-qin 1,YANG Wen-jin 2, FANG Qin 1, CAO Li-min 1
(1. Hyperbaric Oxygen Department; 2. Neurosurgery Department, the People``s Hospital of Pudong New Area in Shanghai, Shanghai 201299, China)

ABSTRACT: Objective To observe the efficacy of hyperbaric oxygen combined oxiracetam on post -traumatic brain syndrome. Methods A total of 96 patients with post-traumatic brain syndrome admitted in our hospital were selected and randomly divided into treatment group and control group, with 48 cases in each group. Patients of the two groups were given conventional treatment, the control group was given oxiracetam drug treatment on the basis of conventional treatment; the treatment group was given hyperbaric oxygen therapy on the basis of the control group. The clinical effect and FIM scores were compared between the two groups. Results The total effective rate of the treatment group was higher than that of the control group (P<0.05). After treatment, the FIM scores of both groups increased, and that of the treatment group was better than the control group (P<0.05). Conclusion The curative effects of hyperbaric oxygen combined oxiracetam on posttraumatic brain syndrome was significant, the hyperbaric oxygen treatment can improve the hypoxia of brain tissue, promote the recovery of brain cell function, and improve the clinical symptoms and patients`` daily living ability, it is worthy of clinical application.
KEYWORDS: oxiracetam; hyperbaric oxygen; post-traumatic brain syndrome

参考文献：
[1] 王忠诚.神经外科学[M].武汉:湖北科学技术出版社,2015:458-460.
[2] 张生荣,王希霞.高压氧治疗脑外伤综合征14 例临床分析[J].实用医技杂志,1998,5(9):662-663.
[3] 王体强,徐楠,王浴生.新型益智药奥拉西坦的药理与临床应用进展[J].四川生理科学杂志,2002,24(4):145-148.
[4] 陈士东.奥拉西坦与高压氧联合治疗血管性痴呆41 例疗效观察[J].医学理论与实践,2011,24(12):1425-1426.
[5] 李佳,刘敏.高压氧治疗颅脑外伤伴视神经损伤患者的疗效观察[J].中国实用神经疾病杂志,2015,18(3):17-18.
[6] 邹坤良.高压氧治疗对脑外伤后患者认知功能障碍的影响[J].医药前沿,2015,31(4):20-21.
[7] 许丽琴,齐旭升,杨敏,等.鼠神经生长因子联合高压氧对缺氧缺血性脑病新生儿血清神经元特异性烯醇化酶和髓鞘碱性蛋白的影 响及疗效观察[J].实用心脑肺血管病杂志,2014,22(4):34-35.
[8] 刘家传,孙文江,张永明,等.高压氧暴露对兔脑爆炸伤后脑组织水 通道蛋白4 的表达及血液灌注的影响[J].中华航海医学与高气压 医学杂志,2012,19(3):163-166.
[9] 谢亮.高压氧治疗对颅脑外伤后偏瘫患者肌力及日常生活能力的 影响[J].中国医师进修杂志,2012,35(32):44-45.
[10] 杨益.高压氧治疗基础与临床[M].上海:上海科学技术出版社,2005:202-204.
[11] 王翠翠,刘晓红,毛蕊琪,等.减压病兔脑和脊髓组织损伤机制及高压氧疗效[J].中华航海医学与高气压医学杂志,2014,21(1):7-10.
[12] 吴亚利,何佳澄.神经节苷酯联合高压氧治疗颅脑外伤疗效观察[J].临床和实验医学杂志,2012,11(4):292-293.