阿司匹林联合氯吡格雷治疗缺血性小卒中的疗效观察

杨云

（岐山县医院神经内科二病区，陕西 宝鸡，722400）

浏览次数：101次 下载次数：313次

摘要：

目的 探讨阿司匹林与氯吡格雷联合治疗缺血性小卒中（IS）的效果，为临床实践提供参考。方法 随机将我院收治的68 例IS 患者分为阿司匹林治疗组和联合用药治疗组，各34 例。对阿司匹林治疗组予以阿司匹林单一用药治疗，对联合用药治 疗组予以阿司匹林和氯吡格雷联合用药治疗。比较两组患者的NIHSS 评分、1 年内复发率、1 年后生活质量。结果 治疗后，阿 司匹林治疗组的NIHSS 评分高于治疗前（P<0.05）；联合用药治疗组的NIHSS 评分低于治疗前和阿司匹林治疗组（P<0.05）。联合用药治疗组的1 年内复发率及1 年后QOL 评分均明显优于阿司匹林治疗组（P<0.05）。结论 对IS 患者予以阿司匹林和 氯吡格雷联合治疗，可以提高治疗效果，降低患者的复发率。

关键词：缺血性小卒中（IS）；阿司匹林；氯吡格雷；联合用药；复发率

中图分类号：R743.31文献标志码：A文章编号：2096-1413(2018)04-0025-02

Effect observation of aspirin combined with clopidogrel in the treatment of ischemic stroke


YANG Yun
(the Second Ward of Neurology Department, Qishan County Hospital, Baoji 722400, China)

ABSTRACT: Objective To explore the effect of aspirin combined with clopidogrel in the treatment of ischemic stroke (IS), so as to provide a reference for clinical practice. Methods Sixty -eight patients with IS admitted in our hospital were randomly divided into aspirin therapy group and combination therapy group, with 34 cases in each group. The aspirin therapy group was treated with aspirin single -agent treatment, the combination therapy group was treated with aspirin combined with clopidogrel. The NIHSS scores, relapse rate within 1 year and quality of life after 1 year were compared between the two groups. Results After treatment, the NIHSS score of the aspirin therapy group was higher than that before treatment (P<0.05). The NIHSS score of the combination therapy group was lower than that of the pre-treatment and the aspirin therapy group (P<0.05). The relapse rate within 1 year and QOL score after 1 year in the combination therapy group were significantly better than those in the aspirin therapy group (P<0.05). Conclusion Aspirin combined with clopidogrel in the treatment of IS can improve the treatment effect, reduce the recurrence rate of patients.
KEYWORDS: ischemic stroke (IS); aspirin; clopidogrel; combination therapy; recurrence rate

参考文献：
[1] 邱麟,高正伟,罗志娟,等.阿司匹林联合氯吡格雷治疗进展性缺血性脑卒中的疗效及对hs-CRP 水平的影响[J].临床军医杂志,2015,43(10):1043-1045.
[2] CASTRO P,AZEVEDO E,SERRADOR J,et al.Hemorrhagic transformation and cerebral edema in acute ischemic stroke: link to cerebral autoregulation[J].J Neurol Sci,2017(372):256-261.
[3] 孟文婷,李东翔,佟玲.缺血性脑卒中的治疗研究进展[J].中国新药 杂志,2016,25(10):1114-1120.
[4] 王班,关天嘉,尤莉莉,等.我国缺血性脑卒中残疾情况及其影响因 素分析[J].中国全科医学,2016,19(2):216-219.
[5] 谢燕贤,娄卫民.缺血性脑卒中患者阿司匹林或氯吡格雷及其联合 应用抗血小板治疗的临床观察[J].中国医药导刊,2016,18(7):697-698.
[6] 商永华,蒋小玲.缺血性脑卒中患者CYP2C19 基因代谢型、联用药物与氯吡格雷抵抗关系的研究[J].福建医药杂志,2016,38(4):65-68.
[7] 温宏峰,王瑞彤,李继来.缺血性脑卒中患者阿司匹林或氯吡格雷及其联合应用抗血小板治疗的研究[J].临床神经病学杂志,2013,26(3):180-182.