奥美拉唑联合雷贝拉唑治疗慢性萎缩性胃炎的临床效果

禹梅1 ，刘婕1，荆成宝1 ，张善弟2*

（1.安康市中心医院，陕西 安康，725000；2.安康市汉滨区第二医院，陕西 安康，725005）

浏览次数：164次 下载次数：336次

摘要：

目的 探讨奥美拉唑联合雷贝拉唑对慢性萎缩性胃炎患者血清胃蛋白酶原（PGⅠ、PGⅡ和PGR）及胃泌素-17（G-17） 水平的影响。方法 选取2016 年3 月至2017 年3 月我院收治的慢性萎缩性胃炎患者86 例，随机分为对照组和试验组，每组 43 例。所有患者均采用阿莫西林、克拉霉素及养胃颗粒进行常规治疗，对照组在此基础上加用奥美拉唑，试验组则加用奥美 拉唑和雷贝拉唑，疗程为8 周。治疗后比较两组患者的临床效果、血清胃蛋白酶原和G-17 水平。结果 试验组总有效率为 93.02%，明显高于对照组的76.74%（P<0.05）；治疗后，两组患者的PGⅠ、PGR、G-17 水平均升高（P<0.05），且观察组PGⅠ、 PGR、G-17 水平高于对照组（P<0.05）。结论 奥美拉唑联合雷贝拉唑治疗慢性萎缩性胃炎临床效果显著，能有效提高胃蛋白 酶及G-17 水平，明显改善患者的临床症状和体征，减轻胃黏膜的炎症反应，可阻止癌前病变的进一步发生，此治疗方案行之 有效，值得临床推广应用。

关键词：奥美拉唑；雷贝拉唑；慢性萎缩性胃炎；胃蛋白酶原；胃泌素-17（G-17）

中图分类号：R573.3文献标志码：A文章编号：2096-1413(2018)04-0006-03

Clinical effect of omeprazole combined with rabeprazole in patients with chronic atrophic gastritis
YU Mei 1, LIU Jie 1, JING Cheng-bao 1, ZHANG Shan-di 2 *
(1. Ankang Central Hospital, Ankang 725000; 2. the Second Hospital of Hanbin District in Ankang, Ankang 725005, China)

ABSTRACT: Objective To discuss the influence of omeprazole combined with rabeprazole on the levels of pepsinogen (PGⅠ, PGⅡ and PGR) and gastrin-17 (G-17) in serum of chronic atrophic gastritis patients. Methods Eighty-six patients with chronic atrophic gastritis admitted in our hospital from March 2016 to March 2017 were selected and randomly divided into control group and experimental group, with 43 patients in each group. All the patients were treated with routine treatment including amoxicillin, clarithromycin and Yangwei particles, while patients in the control group were treated with omeprazole additionally, and patients in the experimental group used omeprazole and rabeprazole based on the routine treatment. The course of treatment was 8 weeks. After treatment, the clinical effects and levels of pepsinogen and G -17 in serum were analyzed and compared between the two groups. Results After treatment, the total effective rate of the experimental group was 93.02%, which was higher than 76.74% of the control group (P<0.05). After treatment, the levels of PGⅠ, PGR and G-17 in the two groups increased, and those of the experimental group were higher than the control group (P <0.05). Conclusion The clinical effect of omeprazole combined with rabeprazole in patients with chronic atrophic gastritis is remarkable. It can significantly improve the levels of pepsinogen and G -17, improve the clinical symptoms and signs of the patients, alleviate the inflammatory reaction of gastric mucosa, and prevent the further occurrence of precancerous lesions. It is an effective treatment methods, which is worthy of clinical application.
KEYWORDS: omeprazole; rabeprazole; chronic atrophic gastritis; pepsinogen; gastrin-17 (G-17)

参考文献：
[1] 杨志,李帅.慢性萎缩性胃炎中医药治疗的概况[J].新疆中医药,2013,31(5):109-112.
[2] 覃琼明,黄益双.慢性萎缩性胃炎的中医药治疗进展[J].内蒙古中医药,2015,34(6):115-116.
[3] 刘烈辉,李捷壮,陈健.黄连素对老年慢性萎缩性胃炎患者血清胃蛋白酶原及胃泌素表达的影响研究[J].中国生化药物杂志,2014,34(8):139-141.
[4] 翟丽颖,孙海英,郭爱华,等.果胶铋与阿莫西林、克林霉素、奥美拉唑联合治疗慢性萎缩性胃炎患者的临床效果分析[J].航空航天医 学杂志,2016,27(6):743-744.
[5] 陈静,王奇,陈军贤.雷贝拉唑与奥美拉唑治疗慢性萎缩性胃炎的 疗效对比研究[J].现代实用医学,2014,26(11):1380-1381.
[6] 中华医学会消化病学分会.中国慢性胃炎共识意见—全国第二 届慢性胃炎共识会议(2006 年上海)[J].现代消化及介入诊疗,2007,12(1):55-62.
[7] 胡建.2 种三联疗法治疗幽门螺旋杆菌阳性十二指肠溃疡疗效比较[J].临床合理用药杂志,2013,6(4):67-68.
[8] 金旭波,方文杰.雷贝拉唑对慢性萎缩性胃炎患者血清胃泌素-17、胃蛋白酶原及胃动素水平影响[J].中国生化药物杂志,2016,36(3):76-78.
[9] 李林,张立新,艾冬琴,等.血清胃蛋白酶原和胃泌素-17 检测在胃癌筛查中的应用[J].海南医学,2015,26(22):3335-3337.
[10] 唐光定,江伟河,黄海深.胃功能四项在胃部疾病和胃癌早期筛查中的应用研究[J].临床医学,2016,36(6):15-17.
[11] 尹志静.雷贝拉唑与奥美拉唑对消化道溃疡的临床疗效对比分析[J].健康必读旬刊,2013,12(11):300-301.
[12] 刘玺,沈明静,缪蕙,等.雷贝拉唑治疗慢性肾脏病并上消化道出血安全性研究[J].中国当代医药,2012,19(6):80.