蔗糖铁注射液和硫酸亚铁片治疗炎症性肠病并发缺铁性贫血的疗效及安全性分析

王锦程1，2

（1. 第四军医大学唐都医院，陕西 西安，710038；2. 西安理工大学校医院，陕西 西安，710032）

浏览次数：190次 下载次数：443次

摘要：

目的 分析蔗糖铁注射液和硫酸亚铁片治疗炎症性肠病合并缺铁性贫血的疗效及安全性。方法 选择我院2012 年1 月 至2017 年3 月我院收治的46 例炎症性肠病合并缺铁性贫血患者为研究对象，随机分为观察组和对照组，每组23 例。观察 组患者静脉滴注蔗糖铁注射液，对照组口服给予硫酸亚铁片。比较两组患者治疗前、后的铁缺乏指标、血红蛋白上升20 g/L 所需的时间及给药安全性。结果 观察组Hb 上升20 g/L 所需平均时间为（11.24±1.18）d，显著短于对照组的（18.72±2.21）d（t= 14.32，P<0.05）。两组患者治疗6 周后的SF、TSAT、sTfRs 水平均较治疗前显著改善，且观察组优于对照组（P<0.05）。两组患者 给药后不良反应总发生率及CRP 水平比较，差异不显著（P>0.05）。结论 静脉铁剂相比口服铁剂能显著改善炎症性肠病合并 缺铁性贫血患者的贫血及缺铁情况，且安全性较高，耐受性好，是一种值得在临床上推广使用的诊治方法。

关键词：炎症性肠病；缺铁性贫血；蔗糖铁注射液；硫酸亚铁

中图分类号：R714.254文献标志码：A文章编号：2096-1413(2018)03-0013-02

Clinical efficacy and safety of iron sucrose injection and ferrous sulfate tablet in the treatment of inflammatory bowel disease complicated with iron deficiency anemia

WANG Jin-cheng1,2
(1. Tangdu Hospital, the Fourth Military Medical University, Xi``an 710032; 2. Xi``an University of Technology Hospital, Xi``an 710032, China)

ABSTRACT: Objective To analyze the clinical efficacy and safety of iron sucrose injection and ferrous sulfate tablet in the treatment of inflammatory bowel disease complicated with iron deficiency anemia. Methods From January 2012 to March 2017, 46 cases of inflammatory bowel disease complicated with iron deficiency anemia patients in our hospital were selected as the research objects, and randomly divided into observation group and control group, with 23 cases in each group. The observation group received iron sucrose injection and the control group received oral ferrous sulfate tablet. The iron deficiency indexes levels before and after treatment, the time required for hemoglobin to rise 20 g/L and administration safety were compared between the two groups. Results The average time required for Hb to rise 20 g/L in the observation group was (11.24±1.18) d, which was significantly shorter than (18.72±2.21) d in the control group (t=14.32, P<0.05). The levels of SF, TSAT and sTfRs in both groups significantly improved after treatment for 6 weeks than before treatment, and those of the observation group were superior to the control group (P<0.05). The difference in the total incidence of adverse reaction after drug treating and CRP levels between the two groups was not significant (P>0.05). Conclusion Compared with orally taking ferrous sulfate tablet, iron sucrose injection can obviously improve the anemia and iron deficiency in patients with inflammatory bowel disease complicated with iron deficiency anemia, with higher safety and tolerance, it is a worthy method in the diagnosis and treatment in clinic.
KEYWORDS: inflammatory bowel disease; iron deficiency anemia; iron sucrose injection; ferrous sulfate

参考文献：
[1] 袁俊华,董爱兰,丁波.炎症性肠病的发病机制及临床诊治研究进展[J].山东医药,2010,50(3):115-116.
[2] 涂梦莹,宋丽君.炎症性肠病的诊断和治疗进展[J].实用儿科临床杂志,2012,27(7):552-556.
[3] GISBERT JP,GOMOLLON F.Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease[J].Am J Gastroenterol,2008,103(5):1299-1307.
[4] LEE TW,KOLBER MR,FEDORAK RN,et al.Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta-analysis[J].J Crohns Colitis,2012,6(3):267-275.
[5] WELLS CW,LEWIS S,BAETON JR,et al.Effects of changes in hemog-
lobin level on quality of life and cognitive function in inflammatory bowel disease patients[J].Inflamm Bowel Dis,2006,12(2):123-130.
[6] 陶科明.炎症性肠病并发缺铁性贫血的诊治[J].胃肠病学和肝病学 杂志,2012,21(2):123-125.
[7] 杨小云,陈春晓.炎症性肠病合并贫血的研究进展[J].国际消化病 杂志,2008,28(6):495-497.
[8] 唐睿晗,陈旻湖.炎症性肠病的贫血与补铁治疗[J].中华消化杂志,2014,34(2):142-144.
[9] 纪程程,高翔.不同给药方式对炎症性肠病合并缺铁性贫血的改善作用比较[J].成都医学院学报,2013,8(3):293-296.
[10] 霍艳宁,杨爱雄.炎症性肠病合并贫血71 例临床分析[J].陕西医学杂志,2014,43(8):1064-1065.