幽门螺杆菌感染与胃蛋白酶原、胃泌素-17相关性研究

杨幸，王璐，董蕾* ，郭晓燕，史海涛，许绍娴

（西安交通大学医学院第二附属医院消化内科，陕西 西安，710004）

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摘要：

目的 研究胃癌高发区陕北安塞县幽门螺杆菌（Hp）感染与血清胃蛋白酶原I（PGI）、胃蛋白酶原II（PGII）、PGI/PGII （PGR）以及胃泌素-17（G-17）浓度的相关性。方法 收集148 例健康查体居民，同时进行13C 呼气试验检测及血清PGI、PGII、 G-17 浓度的检测；根据检测结果，将研究对象分为Hp 阳性组和阴性组，分析比较两组血清PGI、PGII、G-17 浓度及PGR 值变化。结果 Hp 总感染率为40.54%，其中男性感染率为43.08%，女性感染率为38.55%；不同性别Hp 感染率比较，差异不显 著（P>0.05）。Hp 阳性组的血清PGI、PGII、G-17 浓度均高于阴性组，PGR 低于阴性组，差异均具有统计学意义（P<0.05）。PGⅡ 高值组Hp 感染率高于正常值组（P<0.05）。PGR 低值组Hp 感染率高于高值组（P<0.05）。G-17 高值组Hp 感染率高于正常值 组（P<0.05）。结论 HP 感染继发血清中PGI、PGII 及G-17 浓度升高，可作为辅助诊断HP 感染及HP 感染相关性胃病。

关键词：幽门螺杆菌；感染；胃蛋白酶原；胃泌素-17

中图分类号：R573文献标志码：A文章编号：2096-1413(2018)03-0010-03

Correlation study between Helicobacter pylori infection and serum pepsinogen and gastrin-17
YANG Xing, WANG Lu, DONG Lei *, GUO Xiao-yan, SHI Hai-tao, XU Shao-xian
(Gastroenterology Department, the Second Affiliated Hospital of Xi``an Jiaotong University, Xi``an 710004, China)

ABSTRACT: Objective To study the correlation between Helicobacter pylori (Hp) infection and the levels of serum pepsinogen I (PGI), serum pepsinogen II (PGII), PGI/PGII (PGR) and gastrin-17 (G-17) in Ansai County of North of Shaanxi Province which has high incidence of gastric cancer. Methods A total of 148 cases of healthy residents were selected, performing 13C-breath test and serum pepsinogen (PGⅠ/PGII) and gastrin-17 (G-17) levels were detected simultaneously. According to the test results, the subjects were divided into Hp positive group and negative group. The concentration of pepsinogen (PGⅠ/PGII)) and gastrin-17 as well as PGR (PGⅠ/PGⅡ) were analyzed and compared. Results The total infection rate of Hp was 40.54%, of which the male infection rate was 43.08% and the female infection rate was 38.55%, there was no significant difference in the gender (P>0.05). The serum concentrations of PGI, PGII and G-17 in the Hp positive group were higher than those in the negative group and PGR was lower than that in the negative group (P< 0.05). The infection rate of Hp in the high PGⅡ value group was higher than that in the normal value group (P<0.05). Hp infection rate in the low PGR value group was higher than that in the high value group (P<0.05). Hp infection rate in the G-17 high value group was higher than the normal value group (P<0.05). Conclusion PGⅠ, PGII and G-17 concentration increased secondary to Helicobacter pylori infection, which can be used as an auxiliary diagnosis of Hp infection and HP infection-related disease.
KEYWORDS: Helicobacter pylori (Hp); infection; pepsinogen (PG); gastrin-17 (G-17)

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