加速正畸牙齿移动新方法：中药骨碎补局部离子导入

李祎铮1，李永明2 *

（1.浙江中医药大学药学院，浙江 杭州，310053；2.第四军医大学口腔医学院，陕西 西安，710032）

浏览次数：295次 下载次数：480次

摘要：

缩短矫治疗程是口腔正畸医师长期以来关注的重点。以往学者曾尝试了多种方法促进正畸牙周组织的改建以加速牙 齿的移动，但均存在明显的缺陷。中药骨碎补被证明具有改善牙周组织血液循环，促进牙槽骨骨小梁改建等作用，同时中药 离子导入具有使药物直达移动牙齿部位、药效维持时间长、安全、无损害等特点，易于被患者接受。因此，提出一种新方法，通 过中药离子导入技术将中药骨碎补导入正畸移动牙齿的牙周组织内，以促进牙槽骨改建，加速正畸牙齿移动速度，从而缩短 矫治疗程。

关键词：中药；骨碎补；离子导入；正畸牙齿移动

中图分类号：R783.5 文献标志码：A文章编号：2096-1413(2018)01-0194-02

A new approach to accelerate orthodontic tooth movement: local iontophoresis with traditional Chinese herbal

medicine rhizoma drynaria
LI Yi-zheng1, LI Yong-ming2 *
(1. Pharmacy College, Zhejiang Chinese Medical University, Hangzhou 310053; 2. Stomatology College, the Fourth Military Medical University, Xi``an 710032, China)

ABSTRACT: Shortening the treatment course of orthodontics is the focus of orthodontic doctors for a long time. A variety of methods have been tried by scholars in the past to promote the reconstruction of orthodontic periodontium to accelerate the movement of the teeth, however there are obvious defects. It has been approved that the traditional Chinese medicine rhizoma drynaria has the function of improving the circulation of the periodontal tissue and promoting the reconstruction of bone trabecular of alveolar bone and so on; meanwhile the iontophoresis of traditional Chinese medicine has the characteristics of making the drug direct to the position of the moving teeth, the efficacy of the drug is long, safe and no damage, and it is easy to be accepted by the patients. Therefore, this paper proposes a new method: traditional Chinese medicine rhizoma drynaria is imported into the periodontal tissues of orthodontic teeth through the traditional Chinese medicine iontophoresis, to promote alveolar bone remodeling, accelerate the orthodontic tooth movement speed, so as to shorten the course of orthodontic treatment.
KEYWORDS: traditional Chinese medicine; rhizoma drynariae; iontophoresis; orthodontic tooth movement

参考文献：
[1] HUANG H,WILLIAMS RC,KYRKANIDES S.Accelerated orthodontic tooth movement: molecular mechanisms[J].Am J Orthod Dentofacial Orthop,2014,146(5):620-632.
[2] TORRI S,WEBER JB.Influence of low -level laser therapy on the rate of orthodontic movement: a literature review[J].Photomed Laser Surg,2013,31(9):411-421.
[3] MILLIGAN M,ARUDCHELVAN Y,GONG SG.Effects of two wattages of low-level laser therapy on orthodontic tooth movement[J].Arch Oral Biol,2017,80(8):62-68.
[4] 杜婷婷,李静,杜鹤龄,等.加速正畸牙齿移动研究进展[J].中国实用 口腔科杂志,2017,10(2):122-125.
[5] 马洪娜,魏升华,檀龙颜.骨碎补的研究概况[J].中国民族民间医药,2017,26(9):59-65.
[6] 杨同岗,王晓英,郝延科,等.骨碎补抗骨质疏松作用机理的研究进展[J].陕西中医,2017,38(5):677-678.
[7] 丛淑敏,王旭霞,曾婧,等.灌服中药骨碎补、丹参对大鼠正畸牙移动过程中骨密度的影响[J].上海口腔医学,2012,21(4):361-365.
[8] 田刚,张治国,付小伟,等.骨碎补对卵巢切除所致大鼠骨质疏松症的治疗作用及其机理探讨[J].中国中医基础医学杂志,2013,19(1):47-49.
[9] 招文华,沈耿杨,任辉,等.骨碎补活性单体成分调控骨质疏松症相关信号通路的研究进展[J].中国骨质疏松杂志,2017,23(1):122-140.
[10] 史晓治,赵咏芳,郭海玲.骨碎补总黄酮与淫羊藿苷对人骨髓基质干细胞增值及蛋白表达的影响[J].中医学报,2015,30(5):693-695.
[11] 姜自伟,曾景奇,黄枫,等.骨碎补总黄酮促进大鼠牵张成骨新骨形成的影像学研究[J].广州中医药大学学报,2017,34(3):380-393.
[12] WANG Y,WANG XX,ZHANG LN,et al.Effects of traditional chinese medicine on bone remodeling during orthodontic tooth movement[J].J Ethnopharmacol,2012,141(2):642-646.
[13] 孟春力.骨碎补提取物调节成骨细胞活性、增殖及相关基因表达的实验研究[J].海南医学院学报,2017,23(8):1023-1026.
[14] 薄文,张锋利,李平,等.中药离子导入的治疗进展[J].中国中医药现代远程教育,2016,14(22):150-153.
[15] 戴淑香.耳穴贴压联合中药离子导入法治疗气虚血瘀型糖尿病视网膜病变的临床疗效观察[J].世界中西医结合杂志,2017,12(7):978-981.
[16] 沈瑜,冯鑫鑫,陈雷.针刺配合中药离子导入治疗干眼症疗效观察[J].上海针灸杂志,2017,36(3):319-322.