奥美拉唑配合盐酸伊托必利治疗反流性食管炎的疗效及不良反应

马毅

（陕西省榆林市绥德县医院综合内科，陕西 榆林，718000）

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摘要：

目的 研究分析奥美拉唑与盐酸伊托必利联合治疗反流性食管炎的临床疗效及其不良反应发生情况。方法 选取2015 年3 月至2016 年3 月来我院就诊并被诊断为反流性食管炎的患者148 例，随机分为试验组和对照组，各74例。试验组患者采用奥美拉唑配合盐酸伊托必利联合治疗，对照组患者则采用法莫替丁配合盐酸伊托必利联合治疗，观察比较两组患者的 临床疗效及不良发应发生情况。结果 治疗前两组患者反酸、反食及烧灼感症状评分比较，差异无统计学意义（P>0.05），治疗后两组患者反酸、反食及烧灼感症状评分均降低，且试验组明显低于对照组（P<0.05）；治疗后试验组患者治疗总有效率高于 对照组（P<0.05）；两组患者不良反应总发生率比较，差异无统计学意义（P>0.05）。结论 奥美拉唑配合盐酸伊托必利治疗反流 性食管炎疗效确切，且无明显不良反应发生，值得临床上应用。

关键词：奥美拉唑；盐酸伊托必利；反流性食管炎

中图分类号：R571 文献标志码：A文章编号：2096-1413(2018)01-0028-02

Efficacy and adverse reactions of omeprazole and itopride hydrochloride in the treatment of reflux esophagitis
MA Yi
(General Internal Medicine Department, the Hospital of Suide County, Yulin 718000, China)

ABSTRACT: Objective To study the clinical efficacy and adverse reactions of omeprazole combined with itopride hydrochloride in the treatment of reflux esophagitis. Methods One hundred and forty-eight patients with reflux esophagitis admitted in our hospital from March 2015 to March 2016 were selected, and randomly divided into experimental group and control group, with 74 cases in each group. The patients in the experimental group were treated with omeprazole combined with itopride hydrochloride, while the patients in the control group were treated with famotidine combined with itopride hydrochloride, the clinical efficacy and incidence of adverse reactions in the two groups were observed and compared. Results There was no significant difference in the scores of acid reflux, anti-eating and burning sensation between the two groups before treatment (P>0.05). After treatment, the scores of acid reflux, anti-eating and burning sensation significantly decreased, and those in the experimental group were significantly lower than the control group (P<0.05). After treatment, the total effective rate of the experimental group was higher than that of the control group (P<0.05). There was no significant difference in adverse reactions between the two groups after treatment (P>0.05). Conclusion Omeprazole combined with itopride hydrochloride is effective in the treatment of reflux esophagitis, without obvious adverse reaction occuring, and it is worth to be used in clinic.

KEYWORDS: omeprazole; itopride hydrochloride; reflux esophagitis

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