舒血宁注射液治疗眩晕的有效性和安全性Meta 分析

姚苗苗，孔发娣，吴寅，海文利，刘苏利，侯晓叶，冯柯臻

（西安高新医院药剂科，陕西 西安，710075）

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摘要：

目的 采用Meta 分析评价舒血宁注射液治疗眩晕的临床疗效和安全性。方法 治疗组和对照组均使用随机对照试验， 于CNKI、Pubmed、Cochrane 图书馆、中国生物医学文献数据库、中文科技期刊数据库和万方数据库检索相关文献。按照 Cochrane 系统评价的方法进行文献检索和数据提取，用Rev Man 5.3 软件对文献数据进行Meta 分析。结果 本研究纳入18 项 随机对照临床试验，涉及1 682 例患者。Meta 分析结果显示，治疗组的总有效率高于对照组（OR=3.98，95%CI：2.97~ 5.35，P<0.01）。文献未完全明确治疗组全部ADR 例数。结论 舒血宁注射液可有效改善患者眩晕及其他伴随症状，提高治疗 有效率，不增加ADR 的风险，可用于眩晕患者的辅助治疗。

关键词：舒血宁注射液；眩晕；安全性；有效性；Meta 分析

中图分类号：R259 文献标志码：A文章编号：2096-1413(2017)36-0001-04

Meta-analysis of efficacy and safety of Shuxuening injection in the treatment of vertigo
YAO Miao-miao, KONG Fa-di, WU Yin, HAI Wen-li, LIU Su-li, HOU Xiao-ye, FENG Ke-zhen


(Pharmacy Department, Xi``an Gaoxin Hospital, Xi``an 710075, China)

ABSTRACT: Objective To evaluate the clinical efficacy and safety of Shuxuening injection in the treatment of vertigo using the Meta -analysis. Methods Randomized controlled trials were used in both treatment group and control group. Related articles were retrieved in CNKI, Pubmed, Cochrane Library, China Biomedical Literature Database, Chinese Science and Technology Periodical Database and Wanfang Database. Cochrane systematic reviews were used for literature search and data extraction, the literature data were given Meta-analysis by Rev Man 5.3. Results The study included 18 randomized controlled clinical trials, and involved 1 682 cases of patients. Meta-analysis showed that the total effective rate in the treatment group was higher than that in the control group (OR=3.98, 95% CI: 2.97-5.35, P<0.01). The literatures did not fully clear the number of ADR cases in the treatment group. Conclusion Shuxuening injection can effectively improve the dizziness and other accompanying symptoms in patients, and improve the treatment efficiency, without higher risks of ADR, which can be used for the adjuvant treatment of patients with vertigo.
KEYWORDS: Shuxuening injection; vertigo; safety; efficacy; Meta-analysis

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