阿替普酶与尿激酶治疗急性心肌梗死疗效分析

左军1，吴霞2

（1. 陕西省第四人民医院，陕西 西安，710043；2.西北妇女儿童医院，陕西 西安，710061）

浏览次数：61次 下载次数：540次

摘要：

目的 探讨阿替普酶与尿激酶治疗急性心肌梗死的临床效果。方法 选取我院收治的急性心肌梗死患者136 例，随机分 为对照组和观察组，每组68 例。对照组给予尿激酶治疗，观察组则给予阿替普酶治疗。比较两组临床疗效、神经功能缺损程 度和心血管事件发生情况。结果 观察组的治疗总有效率为94.12%，显著高于对照组的76.47%（P<0.05）；治疗后，两组患者 的NIHSS 评分均明显降低，且观察组的NIHSS 评分显著低于对照组（P<0.05）；观察组的心血管事件总发生率明显低于对照 组（P<0.05）。结论 临床上给予急性心肌梗死患者阿替普酶治疗效果显著，不良反应率低，值得临床推广使用。

关键词：急性心肌梗死；尿激酶；阿替普酶

中图分类号：R542.2文献标志码：A文章编号：2096-1413(2017)35-0022-02

Effect analysis of alteplase and urokinase on acute myocardial infarction
ZUO Jun, WU Xia
(1. the Fourth People``s Hospital of Shaanxi, Xi``an 710043; 2. Northwest Women``s and Children``s Hospital,
Xi``an 710061, China)

ABSTRACT: Objective To analyze the effect of alteplase and urokinase on acute myocardial infarction. Methods A total of 136 cases of patients with acute myocardial infarction admitted in our hospital were selected and divided into control group and observation group, with 68 cases in each group. The control group was given urokinase, while the observation group was given alteplase. The curative effect, degree of nervous functional defects and incidence of cardiovascular events were compared between the two groups. Results The curative effect rate in the observation group was 94.12%, which was obviously higher than 76.47% in the control group (P<0.05). After treatment, the NIHSS scores in the two groups were obviously decreased, and the NIHSS score in the observation group was lower than that in the control group (P<0.05). The incidence of cardiovascular events in the observation group was significantly lower than that in the control group (P<0.05). Conclusion For patients with acute myocardial infarction, alteplase has remarkable treatment effect and low incidence of complications, which is worthy of promotion and application.
KEYWORDS: acute myocardial infarction; urokinase, alteplase

参考文献：
[1] 丁淑婧,侯开花,张建华.阿替普酶与尿激酶治疗急性ST段抬高型心肌梗死的疗效对比分析[J].基层医学论坛,2014,18(35):4763-4764.
[2] 李欢.阿替普酶与尿激酶溶栓治疗急性ST 段抬高型心肌梗死临床疗效的对比研究[J].实用心脑肺血管病杂志,2015,23(3):147-148.
[3] 刘浙波,夏豪,童随阳,等.阿替普酶与尿激酶静脉溶栓治疗急性心 肌梗死疗效与安全性的Meta 分析[J].疑难病杂志,2015,14(2):191-195,197.
[4] 李小晶.阿替普酶与尿激酶治疗急性心肌梗死患者的临床疗效分 析[J].中国医药科学,2015,5(13):88-90.
[5] 胡彬.阿替普酶与尿激酶溶栓治疗急性心肌梗死的疗效对比分析[J].实用药物与临床,2013,16(10):960-962.
[6] 刘海燕.阿替普酶静脉溶栓治疗急性心肌梗死老年患者的疗效分析[J].中西医结合心血管病杂志:电子版,2016,4(21):48.
[7] 游波.阿替普酶与尿激酶治疗急性心肌梗死患者的临床疗效分析 [J].医学综述,2012,18(17):2883-2884.