乌拉地尔治疗高血压患者的有效性和安全性分析

邓丽丽，任雪丽，金鑫，吴飞妮，叶靖

（安康市人民医院心血管内科，陕西 安康，725000）

浏览次数：133次 下载次数：318次

摘要：

目的 探讨乌拉地尔对高血压患者的治疗效果及其对患者血压、心率的影响。方法 选取2015年2月至2016年5月在我院接受治疗的120例高血压患者，根据治疗方式分为对照组和观察组，各60 例。对照组患者给予常规治疗，观察组患者在对照组的基础上给予乌拉地尔。观察两组患者的治疗效果。结果 观察组治疗的总有效率为96.67%，高于对照组的86.67%（P<0.05）；治疗后，两组血压水平均明显降低，SDNN、SDANN、RMSSD 和PNN50 水平均明显提升，且观察组明显优于对照组 （P<0.05）。结论 乌拉地尔对高血压治疗效果较好，具有临床推广应用价值。

关键词：乌拉地尔；高血压；心率；不良反应

中图分类号：R544.1文献标志码：A文章编号：2096-1413(2017)34-0035-02

Efficacy and safety analysis of urapidil in the treatment of patients with hypertensive
DENG Li-li, REN Xue-li, JIN Xin, WU Fei-ni, YE Jing
(Cardiovascular Medicine Department, Ankang People``s Hospital, Ankang 725000, China)

ABSTRACT: Objective To investigate the effect of urapidil in patients with hypertensive and its influence on blood pressure and heart rate. Methods One hundred and twenty cases of hypertension patients treated in our hospital from February 2015 to May 2016 were observed and divided into control group and observation group according to treatment methods, with 60 cases in each group. The control group was given routine treatment. The observation group was treated with urapilil on the basis of the control group. The therapeutic effects of the two groups were observed. Results The total effective rate of the observation group was 96.67%, which was higher than 86.67% of the control group (P<0.05). After treatment, the blood pressure levels significantly decrease in both groups, the levels of SDNN, SDANN, RMSSD and PNN50 significantly increased, and those in the observation group were significantly superior to the control group (P <0.05).Conclusion Urapidil is effective in the treatment of hypertension, and it has a value of clinical application.
KEYWORDS: urapidil; hypertension; heart rate; adverse reaction

参考文献：
[1] 谢云燕,秦俭,牛秋丽.乌拉地尔和尼卡地平治疗老年高血压急症 的效果及老年高血压急症的诱因分析[J].中国医药导报,2014,11(13):70-73.
[2] 李艳,王卫,吴延华.卡托普利、硝普钠和乌拉地尔治疗高血压急症 的疗效观察[J].西北药学杂志,2014,29(5):528-529.
[3] 谢云燕,秦俭,牛秋丽.乌拉地尔和尼卡地平对老年高血压急症的 疗效及安全性比较[J].中华老年心脑血管病杂志,2014,16(4):370-373.
[4] MINUSHKINA LO.Treatment of hypertensive emergencies and ma原 lignant hypertension: the possibility of using urapidil [J].Kardiologiia, 2015,54(11):70-74.
[5] 李立新,方宁远.持续静脉泵入乌拉地尔与泵入硝普钠治疗高血压 急症的效果比较[J].西部医学,2015,27(3):356-357.
[6] 付研,王大为.高血压急症与亚急症的血压控制策略[J].中国医刊,2014,49(6):1-5.
[7] 陈玉国.高血压急症药物治疗[J].中国实用内科杂志,2014,34(11):1060-1063.
[8] 王媛.微量泵静脉注射乌拉地尔与尼卡地平治疗老年高血压急症 的临床疗效及安全性[J].临床和实验医学杂志,2016,15(4):367-370.