阿司匹林联合氯吡格雷治疗急性脑梗死的临床效果

党卫军，蒋建华，宋昌军，李娟

（陕西省森工医院神经内科，陕西 西安，710300）

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摘要：

目的 探讨急性脑梗死治疗中应用阿司匹林联合氯吡格雷的临床效果。方法 将我院收治的120 例急性脑梗死患者随 机分成试验组与对照组，每组60 例。试验组患者给予阿司匹林联合氯吡格雷治疗；对照组单服拜阿司匹林。比较两组患者的 缺血事件再发率，治疗前、后的NIHSS 评分与Barthel 指数、hs-CRP 水平及血小板聚集率。结果 试验组治疗后缺血事件再发 率明显低于对照组，差异具有统计学意义（P<0.05）；治疗后，两组患者的NIHSS 评分与Barthel 指数均优于治疗前，且试验组 上述指标评分明显优于对照组（P<0.05）；治疗后，两组患者的血浆hs-CRP 水平和血小板聚集率均优于治疗前，且试验组明 显优于对照组（P<0.05）。结论 阿司匹林联合氯吡格雷的治疗效果与安全性高于单服阿司匹林，具有临床推广价值。

关键词：急性脑梗死；阿司匹林；氯吡格雷

中图分类号：R743.33 文献标志码：A文章编号：02096-1413(2017)33-0046-02

Clinical effect of aspirin combined with clopidogrel in the treatment of acute cerebral infarction
DANG Wei-jun, JIANG Jian-hua, SONG Chang-jun, LI Juan
(Department of Neurology, Shaanxi Sengong Hospital, Xi``an 710300, China)

ABSTRACT: Objective To evaluate the clinical efficacy of aspirin combined with clopidogrel in the treatment of acute cerebral infarction. Methods One hundred and twenty acute cerebral infarction patients admitted in our hospital were randomly divided into control group and experimental group, with 30 cases in each group. The experimental group received aspirin combined with clopidogrel, and the control group received aspirin. The ischemic event recurrence rate, NIHSS score, Barthel index, hs-CRP level and platelet aggregation rate before and after treatment were compared between the two groups. Results The ischemic event recurrence rate of the experimental group were lower than that of the control group (P<0.05). After treatment, the NIHSS scores and Barthel indexes were better than those before treatment, and those indexes scores above of the experimental group were better than the control group (P<0.05). After treatment, the hs-CRP levels and platelet aggregation rates were better than those before treatment, and those of the experimental group were better than the control group (P<0.05). Conclusion The efficacy and safety of aspirin combined with clopidogrel in the treatment of acute
cerebral infarction are higher than aspirin alone, which should be widely used in clinic.
KEYWORDS: acute cerebral infarction; aspirin; clopidogrel

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